PMID: 11343929May 10, 2001Paper

Photodynamic therapy enhanced by hyperbaric oxygen in acute endoluminal palliation of malignant bronchial stenosis (clinical pilot study in 40 patients)

European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
F TomaselliF M Smolle-Jüttner

Abstract

Photodynamic tumor therapy (PDT) is based upon a photochemical reaction that is limited by the availability of molecular oxygen in the target tissue. The use of hyperbaric oxygenation (HBO) increases the amount of oxygen available for the process may thereby enhance the efficacy of PDT. We proved in a prospective, non-randomized clinical pilot study the acute effects on malignant bronchial stenosis and the technical feasibility of combined PDT/HBO. Forty patients (29 males, 11 females, mean age: 64.3 years; range 39-82 years) with inoperable, advanced malignant bronchial tumor stenosis were studied prospectively. Photosensitization was carried out using a hematoporphyrin-derivative 2 mg/kg bw 48 h prior to PDT. The light dose was calculated as 300 J/cm fiber tip. The assessment of outcome 1 and 4 weeks after PDT/HBO was done by endoscopy, chest X-ray, spirometry, laboratory parameters, subjective report of dyspnea and Karnofsky performance status. At 1 and 4 weeks after the treatment the patients felt a significant improvement of dyspnea and hemoptysis alongside with an objective subsiding of poststenotic pneumonia, though spirometric parameters revealed no significant difference. A significant reduction of tumor stenosis (P<0....Continue Reading

Citations

Jan 15, 2004·Gastrointestinal Endoscopy·Hoi-Hung ChanWilliam Robert Brugge
Aug 4, 2004·The Lancet Oncology·Stanley B BrownIan Walker
Jul 25, 2006·Medical Hypotheses·Noori S Al-Waili, Glenn J Butler
Jul 23, 2008·Technology in Cancer Research & Treatment·Zheng HuangYang K Chen
Dec 5, 2003·Photochemistry and Photobiology·Zheng HuangFred W Hetzel
Sep 20, 2018·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Qian LiJunle Qu
Nov 2, 2019·Pharmaceuticals·Ludivine LarueCéline Frochot
Aug 27, 2002·Photochemistry and Photobiology·Qun ChenFred W Hetzel
Mar 2, 2021·Advanced Healthcare Materials·Chunyu HuangHuan Zhao

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.