Photodynamic therapy for acne vulgaris: a critical review from basics to clinical practice: part II. Understanding parameters for acne treatment with photodynamic therapy

Journal of the American Academy of Dermatology
Fernanda H SakamotoR Rox Anderson

Abstract

Photodynamic therapy requires a photosensitizer, oxygen, and activating light. For acne, pilosebaceous units are "target" structures. Porphyrins are synthesized in vivo from 5-aminolevulinic acid (ALA), particularly in pilosebaceous units. Different photosensitizers and drug delivery methods have been reported for acne treatment. There are a variety of porphyrin precursors with different pharmacokinetic properties. Among them, ALA and methyl-ester of ALA (MAL) are available for possible off-label treatment of acne vulgaris. In addition, various light sources, light dosimetry, drug incubation time, and pre- and posttreatment care also change efficacy and side effects. None of these variables has been optimized for acne treatment, but a number of clinical trials provide helpful guidance. In this paper, we critically analyze clinical trials, case reports, and series of cases published through 2009. After completing this learning activity, participants should be able to analyze photodynamic therapy using 5-aminolevulinic acid and its derivates for acne treatment, predict the effectiveness and outcomes of photodynamic therapy using different parameters and/or different porphyrin-related photosensitizers, and assess and manage the si...Continue Reading

References

Jan 1, 1987·Dermatologica·G E Piérard
Jun 1, 1996·Journal of Photochemistry and Photobiology. B, Biology·Q PengJ M Nesland
Sep 1, 1996·Journal of Photochemistry and Photobiology. B, Biology·J WebberD Kessel
Feb 15, 1997·The Journal of Surgical Research·J WebberD Fromm
Jul 28, 1999·Lasers in Surgery and Medicine·S KarrerR M Szeimies
Mar 30, 2000·Journal of Photochemistry and Photobiology. B, Biology·P UehlingerN Lange
Aug 22, 2000·The Journal of Investigative Dermatology·W HongcharuR R Anderson
Sep 15, 2000·Archives of Dermatology·Y ItohA Ishibashi
Apr 2, 2005·The Journal of Dermatology·Makoto KimuraNorimichi Kawashima
Nov 30, 2005·Photodermatology, Photoimmunology & Photomedicine·Seok-Beom Hong, Mu-Hyoung Lee
Dec 20, 2005·The Journal of Dermatology·Shohei YokoyamaKatsumi Hanada
Jan 5, 2006·Lasers in Surgery and Medicine·John Strasswimmer, Donald J Grande
Mar 21, 2006·Journal of the American Academy of Dermatology·Stine Regin Wiegell, Hans Christian Wulf
Aug 22, 2006·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Jinda Rojanamatin, Prapawan Choawawanich
Jan 25, 2007·Clinical and Experimental Dermatology·A C KerrS H Ibbotson
Jan 27, 2007·Photodermatology, Photoimmunology & Photomedicine·Matthew J HarriesMichael H Beck
Jun 29, 2007·Acta Dermato-venereologica·Camilla HörfeltAnn-Marie Wennberg
Sep 7, 2007·Photodermatology, Photoimmunology & Photomedicine·R AkaraphanthP Gritiyarangsan
Feb 19, 2008·Contact Dermatitis·J M JungerstedT Agner
Jul 17, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·William J CottrellAllan R Oseroff
Sep 10, 2008·Acta Dermato-venereologica·Jeanette KaaeHans C Wulf
Feb 20, 2009·Lasers in Surgery and Medicine·Fernanda H SakamotoR Rox Anderson

❮ Previous
Next ❯

Citations

Sep 3, 2013·American Journal of Clinical Dermatology·Fiona M Meredith, Anthony D Ormerod
Nov 29, 2013·Photodiagnosis and Photodynamic Therapy·Roberta M F GondimMaurício S Baptista
Jan 25, 2012·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Austin LiuDavid M Ozog
Dec 21, 2012·Indian Journal of Dermatology, Venereology and Leprology·Cristian PintoAriel Hasson
Jun 4, 2014·Dermatologic Clinics·Ali M Rkein, David M Ozog
Jun 17, 2014·Journal of the American Academy of Dermatology·Byong Han SongKwang Joong Kim
Aug 26, 2014·BioMed Research International·Priyam SinhaNarayan Prasad Yadav
Nov 13, 2014·American Journal of Clinical Dermatology·Shinjita Das, Rachel V Reynolds
Nov 21, 2012·Expert Opinion on Drug Safety·Shivani V TripathiSteven R Feldman
Jan 22, 2011·Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology·Jee-Soo AnKee-Chan Moon
Jun 27, 2012·Expert Opinion on Drug Delivery·Nina Dragicevic-Curic, Alfred Fahr
Jan 23, 2016·Lasers in Medical Science·Yale LiuXiaoxiao Wang
Sep 10, 2013·American Family Physician·Sophia Mohammad, David Ruiz
Oct 25, 2016·Methods : a Companion to Methods in Enzymology·Pablo Fonda-PascualPedro Jaen-Olasolo
Nov 29, 2011·Dermatologic Clinics·Jonathan M OlsonMaryam M Asgari
Oct 30, 2016·The Journal of Dermatological Treatment·Sally IbbotsonColin A Morton
Nov 1, 2016·ACS Infectious Diseases·Claire E WestonMatthew J Fuchter
Nov 26, 2016·The Lancet Infectious Diseases·Mark WainwrightMichael R Hamblin
Mar 25, 2017·The British Journal of Dermatology·J BarbaricJ Car
Jan 7, 2014·Lasers in Surgery and Medicine·Rui YinMichael R Hamblin
Jul 28, 2011·Medicinal Research Reviews·Frederick Harris, Lynne Pierpoint
Dec 29, 2015·International Journal of Cosmetic Science·A J Greaves
Nov 8, 2011·Lasers in Surgery and Medicine·Gitika B KharkwalMichael R Hamblin
Apr 27, 2016·The British Journal of Dermatology·M Taylor
Oct 11, 2012·International Journal of Dermatology·Jong Soo HongDae Hun Suh
Mar 10, 2017·American Journal of Clinical Dermatology·Monica BoenMaria M Tsoukas
Oct 26, 2011·The British Journal of Dermatology·C A Morton
Nov 28, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·C A MortonL R Braathen
Jan 3, 2018·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·C SalavastruK Fritz
Dec 19, 2012·Israel Journal of Chemistry·Sulbha K SharmaMichael R Hamblin
Jan 17, 2021·Photodiagnosis and Photodynamic Therapy·Shiqin TaoQihong Qian
Mar 1, 2021·Journal of the American Academy of Dermatology·Evan AustinJared Jagdeo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Basal Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.