Photodynamic therapy for Bowen's Disease (squamous cell carcinoma in situ) current review and update

Photodiagnosis and Photodynamic Therapy
Katie A O'ConnellNathalie C Zeitouni

Abstract

The aim of this review is to provide clinicians with an overview of outcomes in the current literature concerning the use of Photodynamic Therapy to treat Bowen's Disease, also known as Squamous Cell Carcinoma in situ. The review discusses clinical response, recurrence rates, cosmetic outcomes, and adverse effects. Strong evidence shows that PDT is an effective therapy for SCCis with acceptable clinical response rates and lower recurrence rates in comparison to conventional therapies such as cryotherapy and 5-fluorouracil. Furthermore, PDT is associated with superior cosmetic outcomes and is generally well tolerated by patients, with minimal side effects. PDT is especially useful in patients with multiple lesions and those whom are considered to be non-surgical candidates.

Citations

Feb 1, 2020·Photochemistry and Photobiology·Michele M Kim, Arash Darafsheh
Feb 23, 2020·Photochemistry and Photobiology·Edward V Maytin, Tayyaba Hasan
Apr 25, 2020·Photodiagnosis and Photodynamic Therapy·Min-Feng WuHong-Wei Wang
Nov 11, 2020·Cryobiology·Prashant Srivastava, Amitesh Kumar
Nov 16, 2021·Journal of the Egyptian National Cancer Institute·Nafiseh Sobhani, Ali Akbar Samadani

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