PMID: 11332037May 3, 2001Paper

Photodynamic therapy for malignant mesothelioma: preclinical studies for optimization of treatment protocols

Photochemistry and Photobiology
Hugo SchouwinkFiona A Stewart

Abstract

Effective photodynamic therapy (PDT) depends on the optimization of factors such as drug dose, drug-light interval, fluence rate and total light dose (or fluence). In addition sufficient oxygen has to be present for the photochemical reaction to occur. Oxygen deficits may arise during PDT if the photochemical reaction consumes oxygen more rapidly than it can be replenished, and this could limit the efficacy of PDT. In this study we investigated the influence of the drug-light interval, illumination-fluence rate and total fluence on PDT efficacy for the photosensitizer meta-tetrahydroxyphenylchlorin (mTHPC). The effect of increasing the oxygenation status of tumors during PDT was also investigated. PDT response was assessed from tumor-growth delay and from cures for human malignant mesothelioma xenografts grown in nude mice. Tumor-bearing mice were injected intravenously with 0.15 or 0.3 mg.kg-1 mTHPC, and after intervals of 24-120 h, the subcutaneous tumors were illuminated with laser light (652 nm) at fluence rates of 20, 100 or 200 mW.cm-2. Tumor response was strongly dependent on the drug-light interval. Illumination at 24 h after photosensitization was always significantly more effective than illumination at 72 or 120 h. Fo...Continue Reading

References

Jun 1, 1992·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·A RojasJ Denekamp
Jan 11, 1991·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M JirsaM Jirsa
Jun 1, 1991·Radiation Research·T H FosterR Hilf
Sep 1, 1995·Seminars in Surgical Oncology·H Takita, T J Dougherty
Apr 1, 1995·Journal of Photochemistry and Photobiology. B, Biology·L MorletT Patrice
Jan 1, 1994·Annals of Surgical Oncology·H I PassJ W Cole
Dec 1, 1994·Archives of Otolaryngology--head & Neck Surgery·L A LofgrenB M Steinberg
Jan 2, 1993·International Journal of Cancer. Journal International Du Cancer·H B RisU Althaus
Jan 1, 1996·Lasers in Surgery and Medicine·H B RisU Althaus
Feb 1, 1997·Archives of Otolaryngology--head & Neck Surgery·J F SavaryH van den Bergh
Jan 1, 1997·British Journal of Cancer·P BaasE J Rutgers
Oct 23, 1997·International Journal of Cancer. Journal International Du Cancer·K F FanS G Bown
Oct 23, 1997·International Journal of Cancer. Journal International Du Cancer·R B VeenhuizenF A Stewart
Oct 23, 1997·International Journal of Cancer. Journal International Du Cancer·R VeenhuizenF Stewart
Oct 1, 1996·Journal of Clinical Laser Medicine & Surgery·P GrosjeanP Monnier

❮ Previous
Next ❯

Citations

May 27, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Hans-Beat Ris
Aug 19, 2011·Photochemistry and Photobiology·Mathias O Senge, Johan C Brandt
Sep 13, 2006·Journal of Biomedical Optics·Maurice C G AaldersFiona A Stewart
Aug 6, 2010·Seminars in Radiation Oncology·Joseph S Friedberg, Keith A Cengel
Mar 17, 2010·Photodiagnosis and Photodynamic Therapy·Bastiaan KruijtDominic J Robinson
Oct 6, 2009·Lasers in Surgery and Medicine·Bastiaan KruijtDominic J Robinson
Dec 11, 2002·The Surgical Clinics of North America·Sunil Singhal, Larry R Kaiser
May 2, 2018·Lasers in Surgery and Medicine·André F S LuzLuis G Arnaut
Jun 25, 2004·Physics in Medicine and Biology·Soumya Mitra, Thomas H Foster
Jun 7, 2005·Photochemistry and Photobiology·Martijn TriesscheijnFiona A Stewart
Oct 26, 2005·Lasers in Surgery and Medicine·Thorsten KruegerHans-Beat Ris
Aug 22, 2003·Clinical Journal of Oncology Nursing·Carol Brueggen, Mary Ellen Cordes
Nov 2, 2019·Pharmaceuticals·Ludivine LarueCéline Frochot

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.