Photodynamic therapy for oral potentially malignant disorders

Photodiagnosis and Photodynamic Therapy
Xin JinXin Zeng

Abstract

To assess the impact of photodynamic therapy (PDT) parameters in the management of oral potentially malignant disorders (OPMDs). We conducted a systematic review and meta-analysis of studies that assessed the curative effect of PDT published in PubMed and Embase until Dec 2018. Random or fixed effects models for pooled estimates calculation were used. A pooled estimate calculation revealed that lesion size decreased by 1.38 cm2 (95% CI: 0.39-2.36) after PDT, and the overall complete response (CR) was 0.52 (95% CI: 0.36-0.68), while partial response (PR) reached 0.82 (95% CI: 0.74-0.88). Subgroup analyses revealed that the lesion response (CR: 0.21 [95% CI: 0.12-0.33]) of oral lichen planus was worse than that of other disease entities. 20% aminolevulinic acid was more effective than other photosensitizers, with the overall CR was 0.68 (95% CI: 0.42-0.86), while the PR was 0.88 (95% CI: 0.76-0.94). Topical use of photosensitizers can yield desirable results, while gargling methylene blue yields poor response (0.82 [95% CI: 0.75-0.88] vs. 0.59 [95% CI: 0.44-0.72], respectively). PDT is an effective treatment modality in the management of OPMDs, the overall efficacy of which is influenced by several factors.

Citations

Feb 1, 2020·Photochemistry and Photobiology·Michele M Kim, Arash Darafsheh
Mar 7, 2021·Pathogens·Anton ValkovMarina Nisnevitch
May 4, 2021·Photodiagnosis and Photodynamic Therapy·Dan YangHongxia Dan
Jul 30, 2021·Oral Diseases·Alexander Ross Kerr, Giovanni Lodi

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