PMID: 2108409Mar 1, 1990Paper

Photodynamic therapy for treatment of head and neck cancer

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
V G Schweitzer

Abstract

Since 1975, photodynamic therapy has reportedly been effective in a variety of head and neck malignancies that failed traditional (conventional) therapy, including surgery, cryotherapy, chemotherapy, hyperthermia, and radiation therapy. Photodynamic therapy consists of the intravenous administration of (di)hematoporphyrin ether, a chemosensitizing drug selectively retained by neoplastic and reticuloendothelial tissues which, when exposed to a 630-nm argon laser, catalyzes a photochemical reaction to release free oxygen radicals, "the cytotoxic" agents responsible for cell death and tumor necrosis. Preliminary investigations have assessed the efficacy of photodynamic therapy in treatment of: (1) superficial "condemned mucosa" or "field cancerization" of the oral cavity and (2) stage III and IV head and neck carcinomas that had unsuccessful conventional therapy. Complete and/or partial remissions were obtained in 11 of 12 patients (16 treatments) with a variety of carcinomas of the nasopharynx, palate and uvula, retromolar trigone, temporal bone, cervical esophagus, and AIDS-related Kaposi's sarcoma of the oral cavity.

References

Nov 1, 1985·Archives of Otolaryngology·G S KellerG U Fisher
Jan 1, 1987·Lasers in Surgery and Medicine·S M WaldowH T Fritts
Jan 1, 1989·Seminars in Surgical Oncology·J S McCaughanJ Walker
Jul 1, 1988·Archives of Otolaryngology--head & Neck Surgery·A L AbramsonJ Brandsma
Nov 1, 1986·Archives of Otolaryngology--head & Neck Surgery·D M HarrisS M Waldow
Nov 1, 1986·Mayo Clinic Proceedings·R C Benson
Jun 1, 1987·Photochemistry and Photobiology·T J Dougherty
Jan 1, 1986·Archives of Otolaryngology--head & Neck Surgery·M J ShikowitzA L Abramson
Jun 1, 1987·The Laryngoscope·A L AbramsonB Winkler
Nov 1, 1987·Photochemistry and Photobiology·J S NelsonM W Berns
Nov 1, 1987·Photochemistry and Photobiology·B P Shumaker, F W Hetzel
Nov 1, 1987·Photochemistry and Photobiology·J S McCaughan
Nov 1, 1987·Photochemistry and Photobiology·G MorstynM Abbott
Apr 1, 1987·Gastrointestinal Endoscopy·H TajiriY Oguro
Aug 1, 1987·Archives of Otolaryngology--head & Neck Surgery·A L AbramsonM J Shikowitz
Sep 1, 1986·Archives of Otolaryngology--head & Neck Surgery·J L GluckmanS Peerless
Jun 1, 1985·Archives of Otolaryngology·D E SchullerR P Rock
Feb 1, 1984·American Journal of Clinical Oncology·A G WileM W Berns
Jul 1, 1981·The Journal of Investigative Dermatology·T J Dougherty

❮ Previous
Next ❯

Citations

Jan 1, 1995·Lasers in Surgery and Medicine·A M FisherC J Gomer
Oct 1, 1996·Journal of Clinical Laser Medicine & Surgery·M A Biel
Nov 29, 2001·Photochemistry and Photobiology·R AckroydM Reed
Sep 21, 2007·Photochemistry and Photobiology·Merrill A Biel
Jul 27, 2007·Journal of Dental Research·K Konopka, T Goslinski
Nov 23, 2019·AJNR. American Journal of Neuroradiology·Y FujitaE Kohmura
Sep 1, 1995·Seminars in Surgical Oncology·M A Biel
Jun 23, 2006·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Meike L SchipperSanjiv S Gambhir
Jan 26, 2010·Anais Brasileiros De Dermatologia·Luís TorezanCyro Festa Neto
Nov 17, 2017·Biomaterials Science·Wooram ParkDong-Hyun Kim
Mar 7, 2000·Journal of the Royal Society of Medicine·D C ShackleyJ V Moore
Oct 1, 1995·Journal of Clinical Laser Medicine & Surgery·M B PaivaD J Castro
Jun 22, 2006·Lasers in Surgery and Medicine·M Biel
Apr 1, 1996·European Journal of Oral Sciences·J M NautaA Vermey
Feb 1, 1997·Journal of Clinical Laser Medicine & Surgery·A A EshraghiR E Saxton
May 19, 2006·Photomedicine and Laser Surgery·Jouji NomuraToshiro Tagawa
Dec 6, 2001·Current Oncology Reports·Merrill A Biel
May 2, 2003·Nature Reviews. Cancer·Dennis E J G J DolmansRakesh K Jain
May 1, 2004·Journal of Clinical Laser Medicine & Surgery·Jouji NomuraToshiro Tagawa
Dec 1, 2004·Photodiagnosis and Photodynamic Therapy·R R AllisonC H Sibata

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinosarcoma

Carcinosarcoma is a malignant neoplasm that contains elements of carcinoma and sarcoma so extensively intermixed as to indicate neoplasia of epithelial and mesenchymal tissue. Discover the latest research on carcinosarcoma here.

HIV/AIDS-Related Malignancies

HIV/AIDS infection increases the risk of non-communicable diseases common in the aged including HIV/AIDS-related malignancies. Discover the latest research in HIV/AIDS-related malignancies.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

AIDS Malignancies (ASM)

HIV infection increases the risk of non-communicable diseases common in the aged, including cardiovascular disease, neurocognitive decline, non-aids malignancies, osteoporosis, and frailty. Discover the latest research in AIDS malignancies.