Photodynamic therapy in dermatology: basic principles

Anais Brasileiros De Dermatologia
Luis TorezanCyro Festa Neto

Abstract

Photodynamic therapy involves the administration of a photosensitizing drug and its subsequent activation by light at wavelengths matching the absorption spectrum of the photosensitizer. Currently, topical photodynamic therapy has received approval for the treatment of cutaneous oncologic conditions such as actinic keratoses, Bowen's disease and superficial basal cell carcinoma in many countries in the world. Multicenter randomized controlled studies have demonstrated high efficacy and superior cosmetic outcome over standard therapies. For many non-oncologic dermatological diseases such as acne vulgaris, viral warts and localized scleroderma, case reports and small series have confirmed the potential of photodynamic therapy. After the development of topical photosensitizers 5-aminolevulinic acid (ALA) or its methyl ester (MAL), photodynamic therapy has gained worldwide popularity in dermatology, as these drugs do not induce prolonged phototoxicity as the systemic photosensitizing hematoporphyrin derivatives do. The production of reactive oxygen intermediates such as singlet oxygen depends on the concentration and localization of the photosensitizer in the diseased tissue as well as the applied light dose. Either incoherent lamp...Continue Reading

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Citations

Jun 21, 2012·Anais Brasileiros De Dermatologia·Camila Ferrari RibeiroLuciana Lisboa Faucz
Nov 20, 2016·Photodermatology, Photoimmunology & Photomedicine·Yuri N ChavesCyro Festa Neto
Oct 15, 2010·Anais Brasileiros De Dermatologia·Daniela Rezende NevesJoana Barbosa Alves de Souza
Aug 16, 2012·Anais Brasileiros De Dermatologia·Yuri Nogueira ChavesCiro Festa Neto
Aug 16, 2018·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·B Habermeyer, R Guilard
Jan 25, 2019·Experimental Biology and Medicine·Carlos Dailton Guedes de Oliveira MoraesCristina Pacheco Soares
Jul 7, 2020·The Journal of Dermatological Treatment·Beatrice Martinez Zugaib AbdallaFrancisco Macedo Paschoal
Oct 15, 2010·Anais Brasileiros De Dermatologia·Maria Cláudia Almeida Issa, Mônica Manela-Azulay
Apr 26, 2020·Photodiagnosis and Photodynamic Therapy·Mirian Denise StringasciVanderlei Salvador Bagnato
Dec 4, 2019·Anais Brasileiros De Dermatologia·Clarissa Prieto Herman Reinehr, Renato Marchiori Bakos

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