Photodynamic Therapy in Non-Gastrointestinal Thoracic Malignancies

International Journal of Molecular Sciences
Biniam KidaneKazuhiro Yasufuku

Abstract

Photodynamic therapy has a role in the management of early and late thoracic malignancies. It can be used to facilitate minimally-invasive treatment of early endobronchial tumours and also to palliate obstructive and bleeding effects of advanced endobronchial tumours. Photodynamic therapy has been used as a means of downsizing tumours to allow for resection, as well as reducing the extent of resection necessary. It has also been used successfully for minimally-invasive management of local recurrences, which is especially valuable for patients who are not eligible for radiation therapy. Photodynamic therapy has also shown promising results in mesothelioma and pleural-based metastatic disease. As new generation photosensitizers are being developed and tested and methodological issues continue to be addressed, the role of photodynamic therapy in thoracic malignancies continues to evolve.

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Citations

Jun 4, 2019·Photodermatology, Photoimmunology & Photomedicine·Rebecca L YanovskySteven T Chen
Jun 14, 2019·Annals of the American Thoracic Society·Udit ChaddhaSeptimiu Murgu

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Methods Mentioned

BETA
surgical resection
X-ray
total resection

Clinical Trials Mentioned

NCT02153229
NCT02106559

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