Photodynamic Therapy in the Treatment of Bladder Cancer: Past Challenges and Current Innovations

European Urology Focus
Reema Railkar, Piyush K Agarwal

Abstract

There are limited treatment options for patients with recurrent non-muscle-invasive bladder cancer. In this report, we will talk about the history of photodynamic therapy; although it showed encouraging therapeutic results, it was largely abandoned due to toxicity or bystander effects on normal cells. Monoclonal antibody-conjugates represent an emerging therapeutic approach for malignancies that improves upon tumor specificity. The use of a monoclonal antibody-photosensitizer conjugate is a more selective method of delivering light therapy and has been termed "photoimmunotherapy", which we will discuss in the last part of this report.

Citations

Aug 16, 2019·Expert Opinion on Investigational Drugs·Jennifer TseVitaly Margulis
Jan 23, 2019·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Hao WuTomonori Yano
Aug 6, 2020·Frontiers in Bioengineering and Biotechnology·Pingping WangDi Xu
Nov 18, 2020·Esophagus : Official Journal of the Japan Esophageal Society·Tomoyuki HayashiShuichi Kaneko
Mar 20, 2021·Photodiagnosis and Photodynamic Therapy·Ana Carolina PagliaroneRicardo Carneiro Borra
Jun 5, 2021·Investigative and Clinical Urology·Hyung Suk Kim, Ho Kyung Seo
Jul 14, 2021·Annual Review of Biomedical Engineering·Deanna BroadwaterSophia Y Lunt
Jan 28, 2022·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Wioleta BorzęckaJoão P C Tomé

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