Photodynamic therapy in the treatment of vulvar lichen sclerosus

Photodiagnosis and Photodynamic Therapy
Agnieszka MaździarzBeata Śpiewankiewicz

Abstract

Vulvar lichen sclerosus is a chronic and incurable disease that causes various unpleasant symptoms and serious consequences. The purpose of the study was to assess the effectiveness of photodynamic therapy in the treatment of vulvar lichen sclerosus. Participants in the study included 102 female patients aged 19-85 suffer from vulvar lichen sclerosus. The patients underwent photodynamic therapy (PDT). In the course of PDT the 5% 5- aminolevulinic acid was used in gel form. The affected areas were irradiated with a halogenic lamp PhotoDyn 501 (590-760nm) during a 10-min radiation treatment. The treatment was repeated weekly for 10 weeks. PDT has brought about a good therapeutic effect (complete or partial clinical remission), with 87.25% improvement rate in patients suffering from lichen sclerosus. The greatest vulvoscopic response was observed in the reduction of subepithelial ecchymoses and teleangiectasia (78.95%), and the reduction of erosions and fissures (70.97%). A partial remission of lichenification with hyperkeratosis was observed in 51.61% of cases. The least response was observed in the atrophic lesions reduction (improvement in 37.36% of cases). Our patients suffering from vulvar lichen sclerosus demonstrated positi...Continue Reading

Citations

Dec 23, 2017·Journal of Lower Genital Tract Disease·Anastasia ProdromidouVasilios Pergialiotis
May 19, 2020·The Journal of Dermatological Treatment·A DeclercqP De Haes
Jan 17, 2019·The Journal of Dermatological Treatment·Khoa Nguyen, Amor Khachemoune
Apr 5, 2019·Oncology Letters·Mircea TampaSimona-Roxana Georgescu
Dec 15, 2020·Photodiagnosis and Photodynamic Therapy·Aleksandra ZielińskaEwa Dmoch-Gajzlerska
Jun 20, 2020·Dermatology : International Journal for Clinical and Investigative Dermatology·Giuseppe MonfrecolaPiergiacomo Calzavara-Pinton

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