Photodynamic therapy in VEGF inhibition non-responders-Pharmacogenetic study in age-related macular degeneration assessed with swept-source optical coherence tomography.

Photodiagnosis and Photodynamic Therapy
Slawomir J TeperEdward Wylegala

Abstract

Treatment of neovascular age-related macular degeneration (nAMD) remains a major challenge in ophthalmology. It is essential to determine which of VEGF inhibition non-responders can benefit from photodynamic therapy (PDT). As AMD is strongly related to gene polymorphisms, genetic factors can modify efficacy of treatment. Swept-source optical coherence tomography (SS-OCT) gives exceptional insight into the retina and choroid. SS-OCT usefulness needs to be evaluated in nAMD patients. Prospective 6-month study included consecutive 110 patients (110 eyes) with predominantly classic neovascular AMD treated with photodynamic therapy. Only non-responders to anti-VEGF were included in the study. Greatest linear dimension (GLD) of the lesion, best corrected visual acuity (BCVA), central subfield macular thickness (CSMT) and central choroidal thickness were assessed and compared between CFH and ARMS2 genotype groups. Success rate was the main endpoint. It was defined as not active CNV in the center of the fovea and no worsening in BCVA. Multiple regression was used to assess gene polymorphisms influence on PDT results. Wilcoxon tests were performed to determine significance of changes from baseline values. Following genotype frequencies ...Continue Reading

References

Feb 2, 2012·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Sławomir J TeperEdward Wylęgała
Jan 23, 2013·Ophthalmology·Stephanie A HagstromUNKNOWN Comparison of AMD Treatments Trials Research Group
Aug 20, 2014·The British Journal of Ophthalmology·Ursula Schmidt-ErfurthUNKNOWN European Society of Retina Specialists
Sep 4, 2014·The British Journal of Ophthalmology·Zizhong HuQinghuai Liu

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