Photodynamic therapy-mediated DC immunotherapy is highly effective for the inhibition of established solid tumors

Cancer Letters
Nam-Chul JungDae-Seog Lim

Abstract

Dendritic cell (DC)-mediated immunotherapy has not been as effective as expected for most solid tumors. This study demonstrates immune responses against solid tumors mediated by DCs charged with photodynamic therapy (PDT)-induced tumor lysates, which contain the heat shock protein (HSP) 70. PDT tumor lysate-pulsed DC (PDT-DC) inhibited the growth of mammary EMT6 tumors to a greater extent than freeze/thawed tumor lysate-pulsed DC (FT-DC) or PDT tumor lysates. PDT-DC also showed significant anti-tumor effects against fully-established (i.e., late-stage) solid tumors. Taken together, these results suggest that PDT-DC vaccination is more effective than conventional DC therapy for the treatment of cancers.

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Citations

Nov 29, 2013·Photodiagnosis and Photodynamic Therapy·Ron R Allison, Keyvan Moghissi
Feb 3, 2016·Frontiers in Immunology·Lien VandenberkStefaan W Van Gool
Mar 19, 2013·Journal of Healthcare Engineering·Toshihiro KushibikiMiya Ishihara
Feb 22, 2018·International Journal of Molecular Sciences·Barbara MonticoJessica Dal Col
Jan 30, 2020·Journal of Clinical Medicine·Irati Beltrán HernándezSabrina Oliveira
Dec 7, 2017·Oncotarget·Kiyuk ChangDae-Seog Lim
Oct 19, 2017·Experimental and Therapeutic Medicine·Jun WangLi Li Zou
Apr 23, 2020·Frontiers in Immunology·Emanuelle de Souza SantosMilena Botelho Pereira Soares
May 2, 2019·Frontiers in Cell and Developmental Biology·Alfonso Serrano-Del ValleIsabel Marzo
Apr 21, 2018·Biomacromolecules·Santhosh Kalash RajendrakumarIn-Kyu Park

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