PMID: 2942745Jan 1, 1986

Photodynamic therapy of endobronchial tumors

Lasers in Surgery and Medicine
J S McCaughanB H Bethel

Abstract

After presensitization with IV hematoporphyrin derivative (HpD), neoplasms in the tracheobronchial tree of 18 patients were treated by photodynamic therapy (PDT) with 630-nm light from a tunable dye argon laser system delivered through quartz fibers passed through the biopsy channel of a flexible bronchoscope under local anesthesia. Tumor effect was measured by complete response (CR)--no visible tumor in area treated, partial response (PR)--tumor size or degree of obstruction reduced by more than 50% and some response (SR)--tumor or degree of obstruction reduced by more than 20% but less than 50%. One month or less after 30 treatments to 26 areas in 18 patients, there was 40% CR, 57% PR, and 3% SR. All tumors showed at least some response. Since many of these patients had end-stage disease, the effect on the clinical condition and symptoms were evaluated using the Karnofsky Performance Status (KPS), oxygen requirements, and the presence or absence of respiratory symptoms. One month after treatment, 61% were clinically improved, with an increase of the average KPS from 48 to 61. Three patients with stage III primary lung cancer improved from being severely disabled requiring hospitalization to normal activity with effort and liv...Continue Reading

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Citations

Jan 1, 1990·Lasers in Surgery and Medicine·R K DavisR C Straight
Jan 1, 1992·Lasers in Surgery and Medicine·S L Marcus, M H Dugan
May 1, 2004·Photodiagnosis and Photodynamic Therapy·Harubumi KatoTetsuya Okunaka
Nov 1, 1987·Photochemistry and Photobiology·J S McCaughan
Jul 1, 1993·Photochemistry and Photobiology·J P MarijnissenW M Star
Jan 1, 1991·Cancer Investigation·B L Aronoff
Jan 26, 2016·International Journal of Molecular Sciences·Biniam KidaneKazuhiro Yasufuku
Sep 1, 1993·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·A J HouriganH S Schwartz
Sep 1, 1991·Chest·M J Jacobson, J LoCicero
Jan 1, 1989·Seminars in Surgical Oncology·J S McCaughanJ Walker
Oct 11, 1992·The Annals of Thoracic Surgery·J S McCaughanT E Williams
May 18, 2005·Technology in Cancer Research & Treatment·Z Huang
May 20, 2015·The Cochrane Database of Systematic Reviews·Alex MolassiotisJing-Yu Tan
Oct 1, 1988·Scottish Medical Journal·G Hulks, N C Thomson
Feb 20, 1989·The Medical Journal of Australia·G McLennan, D M Roder

Related Concepts

Bronchial Neoplasms
Hematoporphyrin Photoradiation
Hemedonin
Malignant Neoplasm of Lung
Photochemotherapy
Radiation-Sensitizing Effect
WR-246310

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