PMID: 2942745Jan 1, 1986

Photodynamic therapy of endobronchial tumors

Lasers in Surgery and Medicine
J S McCaughanB H Bethel


After presensitization with IV hematoporphyrin derivative (HpD), neoplasms in the tracheobronchial tree of 18 patients were treated by photodynamic therapy (PDT) with 630-nm light from a tunable dye argon laser system delivered through quartz fibers passed through the biopsy channel of a flexible bronchoscope under local anesthesia. Tumor effect was measured by complete response (CR)--no visible tumor in area treated, partial response (PR)--tumor size or degree of obstruction reduced by more than 50% and some response (SR)--tumor or degree of obstruction reduced by more than 20% but less than 50%. One month or less after 30 treatments to 26 areas in 18 patients, there was 40% CR, 57% PR, and 3% SR. All tumors showed at least some response. Since many of these patients had end-stage disease, the effect on the clinical condition and symptoms were evaluated using the Karnofsky Performance Status (KPS), oxygen requirements, and the presence or absence of respiratory symptoms. One month after treatment, 61% were clinically improved, with an increase of the average KPS from 48 to 61. Three patients with stage III primary lung cancer improved from being severely disabled requiring hospitalization to normal activity with effort and liv...Continue Reading


Jun 1, 1985·Archives of Otolaryngology·D E SchullerR P Rock
Dec 2, 1972·Lancet·I DiamondR Jaenicke
Oct 1, 1984·Chest·A Arabian, S V Spagnolo
Nov 1, 1984·Chest·A F Gelb, J D Epstein
Dec 15, 1984·Cancer·J S McCaughanR Roach
Nov 1, 1982·The Annals of Otology, Rhinology, and Laryngology·D A Cortese, J H Kinsey
Jan 1, 1982·Lasers in Surgery and Medicine·A G WileM W Berns
Jun 1, 1984·Archives of Ophthalmology·D T TseR C Kersten
Jan 1, 1984·Lasers in Surgery and Medicine·R A Bruce
Jan 1, 1983·Lasers in Surgery and Medicine·J S McCaughanR Sherman
Mar 1, 1984·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C C SchagP A Ganz
Dec 1, 1982·The Australian Journal of Experimental Biology and Medical Science·G Dougherty
Oct 1, 1983·The Journal of Urology·H HisazumiN Miyoshi
Nov 1, 1980·The Medical Journal of Australia·I J ForbesF J Jacka


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Jan 1, 1992·Lasers in Surgery and Medicine·S L Marcus, M H Dugan
May 1, 2004·Photodiagnosis and Photodynamic Therapy·Harubumi KatoTetsuya Okunaka
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Jul 1, 1993·Photochemistry and Photobiology·J P MarijnissenW M Star
Jan 1, 1991·Cancer Investigation·B L Aronoff
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Sep 1, 1993·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·A J HouriganH S Schwartz
Sep 1, 1991·Chest·M J Jacobson, J LoCicero
Jan 1, 1989·Seminars in Surgical Oncology·J S McCaughanJ Walker
Oct 11, 1992·The Annals of Thoracic Surgery·J S McCaughanT E Williams
May 18, 2005·Technology in Cancer Research & Treatment·Z Huang
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Oct 1, 1988·Scottish Medical Journal·G Hulks, N C Thomson
Feb 20, 1989·The Medical Journal of Australia·G McLennan, D M Roder

Related Concepts

Bronchial Neoplasms
Hematoporphyrin Photoradiation
Malignant Neoplasm of Lung
Radiation-Sensitizing Effect

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