PMID: 2969279Aug 15, 1988

Photodynamic therapy of endobronchial malignancies

Cancer
J S McCaughanJ Walker

Abstract

Forty-nine tumor sites in 31 consecutive patients with tracheobronchial malignant neoplasms were treated with photodynamic therapy (PDT). After sensitization with the intravenous hematoporphyrin derivative (HpD) or its more purified form of dihematoporphyrin ether (DHE), 630 nm of light from a tunable sensitizer argon light system was delivered to the tumor site through the biopsy channel of a flexible bronchoscope. All patients had received, refused, or were ineligible for conventional surgery, ionizing radiation therapy, or chemotherapy. Before or at 1 month after each treatment, tumor response was evaluated according to the following categories: (1) complete response (CR) (no visible abnormality, and negative biopsy specimen and cytology); (2) partial response (PR) (degree of obstruction or size of tumor reduced more than 50%); (3) some response (SR) (degree of obstruction or size of tumor reduced 20% to 50%); and (4) progression (PROG) (degree of obstruction or size of tumor reduced by less than 20%). Results were as follows: (1) 37% of the tumors treated achieved CR; (2) 55% achieved PR; (3) 4% achieved SR; and (4) 4% were categorized as PROG. Complete follow-up was achieved in all patients. Clinical effect was evaluated 1...Continue Reading

References

Dec 2, 1972·Lancet·I DiamondR Jaenicke
Oct 1, 1984·Chest·A Arabian, S V Spagnolo
Nov 1, 1984·Chest·A F Gelb, J D Epstein
Nov 1, 1982·The Annals of Otology, Rhinology, and Laryngology·D A Cortese, J H Kinsey
Mar 1, 1984·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C C SchagP A Ganz

Citations

Jan 1, 1990·Lasers in Surgery and Medicine·J S NelsonM W Berns
Jan 1, 1995·Lasers in Surgery and Medicine·A M FisherC J Gomer
Jul 1, 1990·Journal of Photochemistry and Photobiology. B, Biology·M KaraivanovaH Prokopanov
Feb 1, 1993·Journal of Photochemistry and Photobiology. B, Biology·G A KostenichE A Zhavrid
Jun 1, 1994·Journal of Photochemistry and Photobiology. B, Biology·L C BergstromR D Poretz
May 1, 2004·Photodiagnosis and Photodynamic Therapy·Harubumi KatoTetsuya Okunaka
May 1, 1996·International Journal of Dermatology·C C Frazier
Dec 1, 1996·Photochemistry and Photobiology·P G SpizzirriK P Ghiggino
May 1, 1991·Current Problems in Cancer·D C Ihde, J D Minna
Apr 1, 1989·The Journal of Surgical Research·R R PerryH I Pass
Jan 22, 1998·The Journal of Thoracic and Cardiovascular Surgery·J S McCaughan, T E Williams
Oct 1, 1996·Journal of Clinical Laser Medicine & Surgery·J S McCaughan

Related Concepts

Choking
Bronchial Neoplasms
Bronchoscopic Surgical Procedures
Hemedonin
Photochemotherapy
Tracheal Neoplasms
Porfimer Sodium
WR-246310

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Systemic Juvenile Idiopathic Arthritis

Systemic juvenile idiopathic arthritis is a rare rheumatic disease that affects children. Symptoms include joint pain, as well as fevers and skin rashes. Here is the latest research on this disease.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Pontocerebellar Hypoplasia

Pontocerebellar hypoplasias are a group of neurodegenerative autosomal recessive disorders with prenatal onset, atrophy or hypoplasia of the cerebellum, hypoplasia of the ventral pons, microcephaly, variable neocortical atrophy and severe mental and motor impairments. Here is the latest research on pontocerebellar hypoplasia.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Trichotillomania

Trichotillomania is an impulse control disorder characterized by the recurrent pulling of one's hair resulting in noticeable hair loss. Here are the latest discoveries in this field.

DDX3X Syndrome

DDX3X syndrome is caused by a spontaneous mutation at conception that primarily affects females due to its location on the X-chromosome. DDX3X syndrome has been linked to intellectual disabilities, seizures, autism, low muscle tone, brain abnormalities, and slower physical developments. Here is the latest research.