Photodynamic therapy of epithelial skin tumours using delta-aminolaevulinic acid and desferrioxamine

The British Journal of Dermatology
S FijanB Ortel

Abstract

Photodynamic therapy (PDT) uses photosensitizing drugs, such as porphyrins, and light for cancer treatment. In the present clinical study we employed topical application of the porphyrin precursor delta-aminolaevulinic acid (ALA) in combination with desferrioxamine (df) for the induction of endogenous porphyrin synthesis. Irradiation was performed with a light source consisting of a halogen lamp with a red filter and a fibreoptic device. Irradiances ranged from 50 to 300 mW/cm2. We treated 49 patients with this PDT regimen. In 32 patients we treated a total of 34 superficial basal cell carcinomas (BCCs) and 22 nodular BCCs, in nine patients 43 solar keratoses, and in eight patients 10 lesions of Bowen's disease. After a single treatment, 30 (88.2%) of the superficial and seven (31.8%) of the nodular BCCs, 35 of 43 (81.4%) solar keratoses, and three (30%) of the Bowen's disease lesions showed complete remission. The post-treatment observation period was up to 20 months. Repeat therapy was required in six nodular and four superficial BCCs. Biopsies were obtained before treatment, and at variable intervals after treatment. Topical PDT of skin tumours with ALA-df-induced porphyrins is effective in the management of epithelial skin ...Continue Reading

References

Jul 30, 1992·Journal of Photochemistry and Photobiology. B, Biology·J C Kennedy, R H Pottier
Dec 11, 1992·Journal of the American Academy of Dermatology·C M JonesH L Stoll
Jan 1, 1992·Photochemistry and Photobiology·B W Henderson, T J Dougherty
Jun 1, 1990·Journal of Photochemistry and Photobiology. B, Biology·J C KennedyD C Pross
Nov 1, 1989·Journal of Photochemistry and Photobiology. B, Biology·Z MalikA Faraggi
May 1, 1993·Journal of Photochemistry and Photobiology. B, Biology·K KönigR Steiner
Mar 1, 1993·Journal of Photochemistry and Photobiology. B, Biology·B OrtelH Hönigsmann

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Citations

Jan 1, 1997·Lasers in Surgery and Medicine·Z SmetanaE Ben-Hur
Jul 28, 1999·Lasers in Surgery and Medicine·S KarrerR M Szeimies
May 25, 2007·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·A Sidoroff
Oct 27, 2004·Lasers in Medical Science·Asta JuzenieneJohan Moan
Jan 7, 2004·Advanced Drug Delivery Reviews·Renata Fonseca Vianna LopezMaria Vitória Lopes Badra Bentley
Aug 2, 2001·Clinics in Dermatology·N C ZeitouniA R Oseroff
Nov 19, 2002·Clinics in Dermatology·Katrin A Salva
Dec 10, 1998·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·B ElfssonH Ehrsson
Dec 1, 2005·Photodiagnosis and Photodynamic Therapy·V MadanE Allan
Apr 1, 2010·Chemical Reviews·Jonathan P CelliTayyaba Hasan
Nov 9, 2000·The British Journal of Dermatology·C A MortonR M MacKie
Jun 3, 1999·Clinical and Experimental Dermatology·H A Kurwa, R J Barlow
Mar 22, 2001·Clinical and Experimental Dermatology·C A Morton, A D Burden
Oct 10, 2002·Clinical and Experimental Dermatology·S GrapengiesserA-M Wennberg
May 10, 2002·Journal of Gastroenterology and Hepatology·Ralph S DacostaNorman E Marcon
May 19, 2006·Photomedicine and Laser Surgery·Jouji NomuraToshiro Tagawa
Dec 27, 2007·Photomedicine and Laser Surgery·Maria Wołuń-CholewaWojcieh Warchoł
Nov 1, 1996·The British Journal of Dermatology·C A MortonR M Mackie
Aug 7, 1998·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Y HarthB Kaplan
Mar 25, 2009·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Emily TierneyDavid J Kouba
Jul 20, 2011·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Ikue ShimizuRaymond G Dufresne
Jun 6, 1998·Photodermatology, Photoimmunology & Photomedicine·C FritschJ Krutmann
May 1, 2001·The Journal of Small Animal Practice·A J StellK Langmack
Mar 28, 2008·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Stacey TullRoberta Sengelmann
Nov 1, 1996·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·A D ToscaM N Tzardi
May 31, 2003·The Journal of Dermatological Treatment·M Stapleton, L E Rhodes
Jan 5, 2002·Expert Opinion on Biological Therapy·J A Leman, C A Morton
Jan 5, 2002·Expert Opinion on Investigational Drugs·S A Doggrell
Jan 5, 2002·Expert Opinion on Investigational Drugs·K LangC Fritsch
Jun 13, 2002·The Journal of Dermatological Treatment·E L Taylor, S B Brown
Aug 18, 2009·Photodiagnosis and Photodynamic Therapy·Abdel-Megid MamoonLisa M Miller
May 8, 1999·The Journal of Investigative Dermatology·S LangerA E Goetz
May 20, 2008·Seminars in Cutaneous Medicine and Surgery·Mollie A MacCormack
Oct 24, 2007·Gynécologie, obstétrique & fertilité·M AscencioS Mordon

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