Photodynamic therapy of superficial esophageal cancer with a transparent hood

Gastrointestinal Endoscopy
Tetsuya NakamuraAkira Terano

Abstract

To improve the effectiveness of photodynamic therapy, the further development of endoscopic devices is essential. For photodynamic therapy of superficial esophageal cancer, a transparent hood was used to obtain precise laser irradiation. The transparent hood was attached to the tip of an upper endoscope. Forty-eight hours after the injection of porfimer sodium, cancerous lesions were irradiated with an excimer-dye laser (4 mJ, 80 Hz). Twenty-four hours later, additional irradiation was applied to lesions when the response to the initial irradiation appeared insufficient. Fifteen neoplastic lesions in 7 patients were treated. The initial size of the lesions ranged from 5 to 30 mm in diameter. Histopathologically, there were 9 squamous-cell carcinomas and 6 high-grade squamous dysplastic lesions. All treated lesions disappeared after the first or the second laser irradiation (total energy range 39.1-193.5 J/cm(2)). During follow-up (range 4-51 months), there was no recurrence of the initial lesion in any patient. There was no severe photodynamic therapy related complication. Photodynamic therapy with a transparent hood is an acceptable option for the treatment of superficial esophageal cancer.

Citations

Feb 25, 2005·Gastrointestinal Endoscopy·Joseph C Yarze
Dec 1, 2004·Photodiagnosis and Photodynamic Therapy·D MittonR Ackroyd
Feb 19, 2005·Journal of Clinical Gastroenterology·Herbert C Wolfsen
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Jan 5, 2017·The Korean Journal of Internal Medicine·Han Hee LeeTayyaba Hasan
May 20, 2020·Clinical Endoscopy·Takahiro Inoue, Ryu Ishihara

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