Photodynamic therapy outcome for oral verrucous hyperplasia depends on the clinical appearance, size, color, epithelial dysplasia, and surface keratin thickness of the lesion

Oral Oncology
Chuan-Hang YuChun-Pin Chiang

Abstract

Our previous studies showed that oral verrucous hyperplasia (OVH) lesions can be successfully treated with a topical 5-aminolevulinic acid-mediated photodynamic therapy (topical ALA-PDT) protocol using a 635-nm light-emitting diode light source. In this study, we report the clinical outcomes of 36 OVH lesions treated by this protocol and assess what clinicopathological parameters of OVH lesions could influence PDT treatment outcomes. We found that all the 36 OVH lesions showed complete response (CR) after an average of 3.8 (range, 1-6) treatments of topical ALA-PDT. OVH lesions with an clinical appearance of a mass, with the greatest diameter <1.5 cm, with the pink color, with epithelial dysplasia, or with the surface keratin layer < or =40 microm needed significantly less mean treatment numbers of PDT to achieve a CR than OVH lesions with an outer appearance of a plaque or a combination type of peripheral plaque and central mass (p=0.000), with the greatest diameter > or =1.5 cm (p=0.011), with the white color (p=0.000), without epithelial dysplasia (p=0.043), or with the surface keratin layer > 40 microm(p=0.003), respectively. Multivariate analysis showed that only the clinical appearance of OVH lesions was the independent f...Continue Reading

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Citations

Jul 31, 2013·Journal of Photochemistry and Photobiology. B, Biology·Ana Rita BarcessatLuciana Corrêa
Nov 14, 2013·International Journal of Dentistry·Thomas George KallarakkalRosnah Binti Zain
Sep 6, 2014·Journal of Photochemistry and Photobiology. B, Biology·Irina dos Santos Miranda CostaMaria Bernadete Riemma Pierre
May 6, 2015·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Hsin-Ming ChenChun-Pin Chiang
Aug 7, 2009·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Yi-Ping WangChun-Pin Chiang
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Sep 15, 2012·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Chuan-Hang YuChun-Pin Chiang
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Nov 21, 2020·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Antonio RomanoAlberta Lucchese
Jun 19, 2021·Journal of Dental Sciences·Ming-Jay HwangChun-Pin Chiang

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