Photodynamic therapy with verteporfin for anterior segment neovascularizations in neovascular glaucoma

American Journal of Ophthalmology
M Battaglia Parodi, Pierluigi Iacono

Abstract

To evaluate photodynamic therapy (PDT) with verteporfin for iris and angle neovascularization in eyes with neovascular glaucoma. Interventional case series. A prospective, noncomparative case series included four patients (four eyes) with neovascular glaucoma. PDT was performed following the parameters of treatment of age-related macular degeneration with photodynamic therapy Study Group (TAP). The laser was directed at the anterior chamber angle and iris surface using a Goldmann three-mirror contact lens. Iris and angle neovascularization were quantified using the number of clock hours involved. Outcome measures were obliteration of neovascularization and decrease of intraocular pressure (IOP). One week after PDT, we registered complete obliteration of angle neovascularization and partial occlusion of iris neovascularization. Subsequent reopening of angle neovascularization was detectable at 1 month. Intraocular pressure diminished considerably after 1 week, with a subsequent tendency toward stabilization. Photodynamic therapy can be used safely and effectively in the early phases of neovascular glaucoma to achieve angle neovascularization obliteration and IOP reduction.

Citations

Oct 24, 2006·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·K U Löffler
Feb 14, 2008·Lasers in Medical Science·C Z LiY Gu
Aug 31, 2007·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Stefan MennelMichael Stur
Jun 29, 2011·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Spyridon K CharisisMiltiadis K Tsilimbaris
Dec 2, 2010·Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye·Maurizio Battaglia ParodiFrancesco Bandello
May 29, 2007·Journal of Cataract and Refractive Surgery·Ali AyataMurat Sönmez
Apr 17, 2008·Clinical & Experimental Ophthalmology·Maurizio Battaglia ParodiGiuseppe Ravalico
Oct 4, 2005·Ophthalmology·Maurizio Battaglia Parodi, Pierluigi Iacono
Sep 12, 2015·Biochemical and Biophysical Research Communications·Wei-Sheng ChenNoorjahan Panjwani
Sep 2, 2014·Veterinary Ophthalmology·Amy TreadwellRichard R Dubielzig
Jun 21, 2007·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Stefan MennelMichael Stur
Apr 3, 2007·Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye·Maurizio Battaglia ParodiGiuseppe Ravalico

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