Photodynamic therapy with verteporfin for juxtafoveal choroidal neovascularization secondary to pathologic myopia-1-year results of a prospective series

Eye
D S C LamW-M Chan

Abstract

To study the efficacy of photodynamic therapy (PDT) with verteporfin in the treatment of juxtafoveal choroidal neovascularization (CNV) secondary to pathologic myopia. Prospective, open label, two-centre, noncomparative, interventional case series. Consecutive patients with juxtafoveal CNV associated with pathologic myopia were recruited and treated with a standard regimen of PDT with verteporfin. Patients were being followed up every 3-monthly and retreatment was considered when there was evidence of angiographic leakage. Outcome measures included changes in the mean best-corrected visual acuity (BCVA) at the 1-year follow-up when compared with the baseline, the proportion of patients who had stable (within 1 line) and improved visions. A total of 11 eyes from 11 patients with juxtafoveal CNV secondary to pathologic myopia were recruited and all completed the 1-year follow-up. The mean age at presentation was 44.8 years. The refractive error ranged from -6.0 to -15.0 D (+/-SD was -9.55+/-3.04 D). The logMAR BCVA improved from 0.57 to 0.39 at the 1-year follow-up (Wilcoxon signed-ranks test, P=0.027). The mean improvement was 1.8 lines. Five eyes (45.4%) had BCVA improved by >or=3 lines. None of the treated patients had visual ...Continue Reading

References

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Citations

Oct 20, 2005·The British Journal of Ophthalmology·W-M ChanD S C Lam
Nov 21, 2007·The British Journal of Ophthalmology·Juan Reche-FrutosJ Garcia-Sanchez
Dec 14, 2011·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·D Mitry, H Zambarakji
Feb 22, 2011·Photodiagnosis and Photodynamic Therapy·Edyta PaszkoJohn V Reynolds
Sep 10, 2011·Clinical & Experimental Ophthalmology·Danny S NgClement W Chan
May 10, 2012·Progress in Retinal and Eye Research·Kumari NeelamTien Y Wong
Aug 1, 2012·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Rufino Silva
Apr 11, 2006·Japanese Journal of Ophthalmology·Wai-Man ChanDennis S C Lam
Mar 1, 2014·Asia-Pacific Journal of Ophthalmology·Mary HoDennis S C Lam

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