PMID: 9002256Nov 1, 1996Paper

Photodynamic therapy within edematous brain tissue: considerations on sensitizer dose and time point of laser irradiation

Journal of Photochemistry and Photobiology. B, Biology
W StummerC Goetz

Abstract

Photosensitizer is known to spread with vasogenic edema fluid arising from a cerebral lesion (Neurosurg 33:1075-1082, 1993), which may be essential for sensitizing malignant cells outside the main tumor mass. The present experiments seek to elucidate whether resultant necrosis of perifocal brain tissue after laser irradiation follows a corresponding time pattern and whether damage depends on the photosensitizer dose. Male Wistar rats were anaesthetized with chloralhydrate for venous cannulation, craniotomy and focal cold lesion in order to induce vasogenic edema. Simultaneously, Photofrin II (PF II) was administered at a dose of 5 mg kg-1. The animals were re-anaesthetized after either 4, 12 or 24 h for the irradiation of lesion and perifocal tissue with 200 J cm-2 of laser light (630 nm). The brains of other animals were irradiated 4 h after cold lesion with 200 J cm-2 after receiving either 0, 2.5 or 5 mg kg-1 PF II (all groups: n = 6). Resultant necrosis was assessed planimetrically in serial coronal cryosections of brains perfusion fixed 24 h after irradiation. Necrosis was significantly enhanced with irradiation 4 h after cold lesion and photosensitizer (avg. area +/- SD: 4.3 +/- 0.7 mm2) compared with lesion only (0.84 +/...Continue Reading

References

May 1, 1990·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·P J Muller, B C Wilson
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Citations

Dec 1, 2004·Photodiagnosis and Photodynamic Therapy·M Sam Eljamel
Oct 31, 2002·Journal of Neurosurgery·Bernhard OlzowyWalter Stummer
Jun 28, 2012·Sensors·Jiao Chen, Julia Xiaojun Zhao
May 12, 2012·Acta neurochirurgica·Marcel A KampMichael Sabel
May 6, 2015·International Journal of Molecular Sciences·Mustafa El-KhatibJan Frédérick Cornelius
Jan 2, 2010·Nanomedicine : Nanotechnology, Biology, and Medicine·Huichen GuoYong Zhang
Jan 1, 1997·Journal of Clinical Laser Medicine & Surgery
Oct 3, 2000·Lasers in Surgery and Medicine·S KrishnamurthyT Brown
Sep 24, 2020·Current Topics in Medicinal Chemistry·Ke-Tao JinYun-Fang Chen

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