Photodynamic treatment has chondroprotective effects on articular cartilage

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
Lawrence G SullivanChristine A Towle

Abstract

Osteoarthritis (OA) is a disabling joint disease for which there is currently no cure. It is characterized by the destruction of articular cartilage. One strategy that is being explored for protecting the cartilage in OA is the administration of transforming growth factor-beta, which in vitro antagonizes cartilage degradation initiated by catabolic stimulants such as interleukin-1 (IL-1). The problems associated with selective delivery of the growth factor to chondrocytes, undesirable side-effects on joint tissues, and short biological half-life have led us to explore modalities aimed at activating transforming growth factor-beta that is stored in the cartilage as latent complexes. Photodynamic therapy is a two-step protocol of tissue sensitization with a light-activatable chemical called a photosensitizer followed at some interval by irradiation with the appropriate wavelength visible light. Biological effects are typically elicited through oxygen-dependent photochemistry without heat generation. Transforming growth factor-beta1 can be activated by oxidative mechanism(s), prompting us to explore whether photodynamic technology can be harnessed to modulate cartilage metabolism. Disks of bovine articular cartilage were photosens...Continue Reading

References

Aug 1, 1991·Archives of Biochemistry and Biophysics·T I MoralesA B Roberts
Jun 1, 1991·Seminars in Arthritis and Rheumatism·J P PelletierJ Martel-Pelletier
Feb 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·R BachorT Hasan
Jan 1, 1990·Scandinavian Journal of Rheumatology. Supplement·G Loyau, J P Pujol
Jul 14, 1989·Biochemical and Biophysical Research Communications·H J AndrewsB L Hazleman
Dec 30, 1986·Biochemical and Biophysical Research Communications·F OllivierreB V Treadwell
Dec 30, 1988·Biochemical and Biophysical Research Communications·S Chandrasekhar, A K Harvey
Jun 11, 1996·Proceedings of the National Academy of Sciences of the United States of America·E P BöttingerM B Sporn
Apr 1, 1997·Arthritis Care and Research : the Official Journal of the Arthritis Health Professions Association·T A CronanR M Kaplan
Jan 20, 1998·Biochimica Et Biophysica Acta·P MargaronJ G Levy
Jun 24, 1998·Journal of the National Cancer Institute·T J DoughertyQ Peng
Jul 1, 1998·International Reviews of Immunology·N L McCartney-FrancisS M Wahl
Oct 3, 1998·Antimicrobial Agents and Chemotherapy·N S SoukosT Hasan
Dec 5, 1998·Matrix Biology : Journal of the International Society for Matrix Biology·G J van OschH L Verwoerd-Verhoef
Feb 29, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·G O SimkinD W Hunt
Feb 25, 2000·Journal of the American Academy of Dermatology·K KalkaH Mukhtar

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Citations

Oct 20, 2005·Journal of the National Cancer Institute·Marcela G del CarmenTayyaba Hasan
Apr 17, 2008·Lasers in Surgery and Medicine·Rainer J EgliMichael Leunig

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