Photodynamic treatment of the dermatophyte Trichophyton rubrum and its microconidia with porphyrin photosensitizers

Photochemistry and Photobiology
Threes SmijsHans J Schuitmaker

Abstract

The application of photosensitizers for the treatment of fungal infections is a new and promising development within the field of photodynamic treatment (PDT). Dermatophytes, fungi that can cause infections of the skin, hair and nails, are able to feed on keratin. Superficial mycoses are probably the most prevalent of infectious diseases in all parts of the world. One of the most important restrictions of the current therapeutic options is the return of the infection and the duration of the treatment. This is especially true in the case of infections of the nail (tinea unguium) caused by Trichophyton rubrum, an anthropophilic dermatophyte with a worldwide distribution. Recently, we demonstrated that 5,10,15-tris(4-methylpyridinium)-20-phenyl-[21H,23H]-porphine trichloride (Sylsens B) and deuteroporphyrin monomethylester were excellent photosensitizers toward T. rubrum when using broadband white light. This study demonstrates the photodynamic activity of these photosensitizers with red light toward both a suspension culture of T. rubrum and its isolated microconidia. The higher penetration depth of red light is important for the PDT of nail infections. In addition, we tested the photodynamic activity of a newly synthesized porph...Continue Reading

Citations

Dec 1, 2010·Photochemistry and Photobiology·Threes G M Smijs, Stan Pavel
Jan 10, 2012·Photochemistry and Photobiology·Sarit Oriel, Yeshayahu Nitzan
Apr 28, 2005·Antimicrobial Agents and Chemotherapy·S A G LambrechtsJ Van Marle
Nov 28, 2012·Lasers in Medical Science·Jennifer A LedonKeyvan Nouri
Sep 1, 2015·Jundishapur Journal of Microbiology·Ahmad Reza NematollahiEnsieh Nournia

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