Photoexposition discriminates Notch 1 expression in human cutaneous squamous cell carcinoma

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
John PanelosDaniela Massi

Abstract

The Notch signaling pathway may play opposing roles in cancer. It can be oncosuppressive or protumoral, depending on the cellular and tissue context. In skin cancer, Notch 1 expression is downregulated, thus supporting the hypothesis of an oncosuppressive role in cutaneous carcinomas. However, as members of the Notch family undergo downregulation upon exposure to UV irradiation, we wondered whether Notch 1 expression in skin carcinomas may be governed by additional factors, including UV exposure. We investigated the expression of Notch 1 and its ligands, Jagged 1, Jagged 2 and Delta-like 1, by immunohistochemistry in a series of premalignant and invasive cutaneous carcinomas, including 4 solar keratoses, 5 Bowen's disease, 5 squamous cell carcinomas on sun-exposed skin, 6 squamous cell carcinomas on sun-protected genital skin and 14 basal cell carcinomas of different histotypes (nodular, superficial type, sclerodermiform/infiltrating and baso-squamous). Expression of Notch 1 was decreased in solar keratoses and invasive squamous cell carcinomas localized on sun-exposed skin. In contrast, marked Notch 1 staining was observed in extragenital Bowen's disease as well as in genital (penile) human papilloma virus-related in situ and ...Continue Reading

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Citations

Jan 25, 2013·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·P SeverinoE B Souto
Apr 28, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·John PanelosDaniela Massi
Mar 20, 2014·British Journal of Cancer·H ZhangY Sun
Aug 6, 2014·Biochemical and Biophysical Research Communications·Aadithya ArumugamMohammad Athar
Jan 15, 2016·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Tonghan ZhangGui-Qing Liao
Jan 15, 2016·Journal of Cutaneous Pathology·Jason F SolusAndrás Schaffer
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Sep 8, 2010·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Tong-Han ZhangGui-Qing Liao
Nov 1, 2011·Molecular and Cellular Biochemistry·Zhipeng WangYukun Wang
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Aug 12, 2015·International Journal of Surgical Pathology·Jason F SolusStefan Kraft
Jun 16, 2018·Oncogene·Eunmiri RohZigang Dong
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Apr 6, 2018·International Journal of Molecular Medicine·Eva SkarmoutsouClaudio Guarneri
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