PMID: 8595166Feb 1, 1996Paper

Photofrin accumulation in malignant and host cell populations of various tumours

British Journal of Cancer
M Korbelik, G Krosl

Abstract

Photofrin accumulation in malignant and host cell populations of various tumours was studied by flow cytometry analysis of cells dissociated from the tumour tissue. The transplantable mouse tumour models included in this analysis were sarcomas EMT6, RIF, KHT and FsaN, Lewis lung carcinoma, SCCVII squamous cell carcinoma (SCC) and slowly growing moderately differentiated AT17 SCC. An example of spontaneous mouse adenocarcinoma was also examined. Staining with specific monoclonal antibodies was used to identify the various cell populations present in these tumours. The main characteristic of Photofrin cellular accumulation was a very high photosensitiser content found exclusively in a subpopulation of tumour-associated macrophages (TAMs). Photosensitiser levels similar to or lower than in malignant cells were observed in the remaining TAMs and other tumour-infiltrating host cells. Photofrin accumulation in malignant cells was not equal in all tumour models, but may have been affected by tumour blood perfusion/vascularisation. Results consistent with the above findings were obtained with SCC of buccal mucosa induced by 9,10-dimethyl-1,2-benzanthracene in Syrian hamsters. The TAM subpopulation that accumulates by far the highest ce...Continue Reading

Citations

Jun 6, 2000·British Journal of Cancer·M KorbelikD J Chaplin
Mar 6, 2007·Expert Opinion on Drug Delivery·Giuseppe Palumbo
Feb 23, 2012·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Mladen KorbelikDuska Separovic
Oct 25, 2000·Photochemistry and Photobiology·M R HamblinB Ortel
Nov 8, 2011·Lasers in Surgery and Medicine·Mladen KorbelikDuska Separovic
Oct 1, 1996·Journal of Clinical Laser Medicine & Surgery·M Korbelik
Jun 3, 2004·International Journal of Immunopathology and Pharmacology·T N Demidova, M R Hamblin
Sep 2, 2006·Cancer Immunology, Immunotherapy : CII·Brandon Stott, Mladen Korbelik
Sep 21, 2007·Photochemistry and Photobiology·Ivana CecicMladen Korbelik
Apr 3, 2013·The Journal of Membrane Biology·Joanna WezgowiecMalgorzata Kotulska
Jan 27, 2015·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Mladen Korbelik, Michael R Hamblin
Nov 29, 2001·Photochemistry and Photobiology·I CecicM Korbelik
Sep 22, 2015·Cellular & Molecular Immunology·Hing-Yuen YeungWing-Ping Fong

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.