PMID: 9180236Jun 1, 1997Paper

Photofrin-mediated photodynamic therapy of chemically-induced premalignant lesions and squamous cell carcinoma of the palatal mucosa in rats

International Journal of Oral and Maxillofacial Surgery
J M NautaJ L Roodenburg

Abstract

Photodynamic therapy (PDT), an experimental cancer therapy, was studied in an animal model of chemically-induced epithelial dysplasia and squamous cell carcinoma. PDT was performed 24 hours after i.v. injection of 2.5 mg/kg bw Photofrin, and using 100 J/cm2 incident light at two activation wavelengths (514.5 nm or 625 nm). Two days after PDT, the majority of rats macroscopically showed a marked erythema of the entire palatal region. Microscopically all the rats showed oedema, haemorrhage, and necrosis of the epithelium of the intermolar area. The long-term results were not so favourable. No evidence of disease was found in 6 out of 20 rats in the 514.5 nm group and in 2 out of 20 rats in the 625 nm treated group. Epithelial dysplasia was found in 14 out of 20 rats in the 514.5 nm group, and in 18 out of 20 rats of the 625 nm treated group. Squamous cell carcinomas were found in 4 out of 20 rats treated with 514.5 nm and in 7 out of 20 rats in the 625 nm treated groups. Comparing both treatment wavelengths, better results were obtained in the 514.5 nm groups as this wavelength gave less normal tissue damage. Based on the results of this study the application of PDT for the treatment of field cancerization and squamous cell carci...Continue Reading

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Citations

Nov 4, 2004·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Hamid R DjalilianFrank G Ondrey
Jun 3, 2000·Journal of Photochemistry and Photobiology. B, Biology·J T van den AkkerH J Sterenborg
Apr 7, 2011·Lasers in Medical Science·Flávia Zardo TrindadeCarlos Alberto de Souza Costa
Jul 14, 1998·International Journal of Oral and Maxillofacial Surgery·M UeharaM B Pe
Dec 30, 1998·International Journal of Oral and Maxillofacial Surgery·A KüblerJ Mühling
Sep 30, 2015·Bioscience Reports·Zenildo Santos SilvaMichael R Hamblin

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