Photofunctionalised Ti6Al4V implants enhance early phase osseointegration

Bone & Joint Research
R YamauchiY Ishibashi

Abstract

Ultraviolet (UV) light-mediated photofunctionalisation is known to improve osseointegration of pure titanium (Ti). However, histological examination of titanium alloy (Ti6Al4V), which is frequently applied in orthopaedic and dental surgery, has not yet been performed. This study examined the osseointegration of photofunctionalised Ti6Al4V implants. Ti and Ti6Al4V implants were treated with UV light, and the chemical composition and contact angle on the surfaces were evaluated to confirm photofunctionalisation. The implants were inserted into femurs in rats, and the rats were killed two or four weeks after the surgery. For histomorphometric analysis, both the bone-implant contact (BIC) ratio and the bone volume (BV) ratio were calculated from histological analysis and microcomputed tomography data. The amount of carbon and the contact angle on both implants were significantly reduced after UV irradiation. The BIC ratios for both UV light-treated implants significantly increased at two weeks, but there was no significant difference at four weeks. There was no significant difference in the BV ratios between the UV light-treated and control implants at two or four weeks. This study suggests that photofunctionalisation of Ti6Al4V im...Continue Reading

References

Aug 23, 2006·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Jianhua WeiYutaka Oda
Apr 18, 2008·Clinical Oral Implants Research·Takashi SawaseMitsuru Atsuta
Aug 1, 2008·Journal of the Royal Society, Interface·M NavarroJ A Planell
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Citations

Apr 24, 2018·Bone & Joint Research·J ZiebartA Jonitz-Heincke
May 18, 2020·Journal of Biomedical Materials Research. Part a·Jésica ZuchuatOscar Decco
Sep 20, 2020·Journal of Orthopaedic Surgery and Research·Sho KanekoYasuyuki Ishibashi
Jun 24, 2020·Journal of Biomaterials Applications·Cristian Padilha FontouraCesar Aguzzoli
Dec 4, 2019·ACS Applied Materials & Interfaces·Lin XuJianning Ding

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Methods Mentioned

BETA
electron spectroscopy
X-ray
light microscopy

Software Mentioned

ImageJ
SPSS

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