Photogenerated Hole-Induced Chemical Redox Cycling on Bi2 S3 /Bi2 Sn2 O7 Heterojunction: Toward General Amplified Split-Type Photoelectrochemical Immunoassay

ACS Sensors
Jun-Tao CaoWei-Wei Zhao

Abstract

This work reports the elegant bridging of enzymatic generation of electron donor with photogenerated hole-induced chemical redox cycling amplification (RCA) for innovative photoelectrochemical (PEC) immunoassay, by the aid of a heterojunction photoelectrode with split-type strategy. Specifically, the system was exemplified by the alkaline phosphatase (ALP) catalytic generation of ascorbic acid (AA), the redox cycling of AA by tris (2-carboxyethyl) phosphine (TCEP) as reductant, and the use of a novel Bi2S3/Bi2Sn2O7 heterojunction and myoglobin (Myo) as the photoelectrode and the target, respectively. After the immunoreaction and ALP-induced production of AA, the subsequent oxidation of AA by the photogenerated holes of the Bi2S3/Bi2Sn2O7 heterojunction could be cycled via the regeneration of AA by TCEP from the oxidized product of dehydroascorbic acid, leading to easy signal amplification for the sensitive immunoassay of Myo in real samples. It is believed that this work provided a basis for further design and development of general RCA-based PEC immunoassays.

References

Feb 19, 2013·Chemical Communications : Chem Comm·Panpan WangJiadong Huang
Jun 17, 2014·Chemical Reviews·Wei-Wei ZhaoHong-Yuan Chen
Aug 26, 2014·ACS Applied Materials & Interfaces·Xianxiang ZengZhihui Dai
Sep 17, 2014·Chemical Society Reviews·Wei-Wei ZhaoHong-Yuan Chen
Aug 2, 2017·ACS Applied Materials & Interfaces·Pei Pei LiuHuangxian Ju
Nov 15, 2017·Analytical Chemistry·Wei-Wei ZhaoHong-Yuan Chen

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Citations

Nov 14, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Lan GeWang Kun
Mar 16, 2021·Nanoscale·Yichuan Chen, Mengtao Sun

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