Photographic estimation of the duration of high dose intravitreal triamcinolone in the vitrectomised eye

The British Journal of Ophthalmology
B R KosobuckiLingyun Cheng

Abstract

To determine the duration of residence of triamcinolone in the vitrectomised eye. 23 eyes of 23 patients underwent intravitreal injection of high dose (20 mg) decanted triamcinolone acetonide (Kenalog) at the conclusion of vitrectomy surgery or in previously vitrectomised eyes with macular oedema from diabetes, uveitis, cataract surgery, or other surgery. The median time to disappearance of triamcinolone in the vitrectomised eye was 113 days (95% confidence interval (CI) 85 to 191). In the phakic eyes the median time to disappearance was 191 days (95% CI 148 to 191). In the pseudophakic eyes the median time to disappearance was 102 days (95% CI 85 to 113). This difference was not significant (p = 0.12). There were no cases of endophthalmitis or severe inflammatory reaction. Five eyes (22%) experienced intraocular pressure rise >/=10 mm Hg. High dose decanted intravitreal triamcinolone has a median residence time of 113 days in the vitrectomised eye. Although this appears to be shorter than in the non-vitrectomised eye, this study suggests that a sufficient duration of action will be present to be clinically useful.

Associated Clinical Trials

References

Nov 21, 1975·Documenta Ophthalmologica. Advances in Ophthalmology·G A PeymanH I Meisels
Aug 1, 1974·Archives of Ophthalmology·R O Graham, G A Peyman
Feb 1, 1993·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Y N HuiK Heimann
Dec 8, 1998·Australian and New Zealand Journal of Ophthalmology·J K ChallaF A Billson
Jan 21, 2000·Australian and New Zealand Journal of Ophthalmology·R J Wingate, P E Beaumont
Feb 25, 2000·BMJ : British Medical Journal·P J McCluskeyS Lightman
Sep 1, 2000·The British Journal of Ophthalmology·J B JonasS Panda-Jonas
Mar 29, 2001·Clinical & Experimental Ophthalmology·S YoungS Lightman
Sep 1, 2001·American Journal of Ophthalmology·J B Jonas, A Söfker
Jan 30, 2002·The British Journal of Ophthalmology·Paul B GreenbergElias Reichel
Nov 1, 1995·Australian and New Zealand Journal of Ophthalmology·P L PenfoldF A Billson
May 3, 2002·Ophthalmology·Adam MartidisCaroline Baumal
Aug 20, 2002·The British Journal of Ophthalmology·Jost B Jonas
Sep 25, 2002·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Jost B JonasRobert F Degenring
Dec 19, 2002·The British Journal of Ophthalmology·J B JonasR Degenring
Jan 14, 2003·Archives of Ophthalmology·Jost B JonasRobert F Degenring
Jan 29, 2003·Journal of Cataract and Refractive Surgery·Mandi D ConwayGholam A Peyman
Feb 5, 2003·American Journal of Ophthalmology·Nathanael BenhamouAlain Gaudric
Mar 5, 2003·American Journal of Ophthalmology·Leon A Bynoe, Jeffrey N Weiss
Mar 19, 2003·The British Journal of Ophthalmology·J B JonasR Degenring
Mar 26, 2003·Retina·Clarion D Alldredge, Bruce R Garretson
Jul 31, 2003·American Journal of Ophthalmology·Jost B JonasRobert F Degenring
Aug 28, 2003·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Jost B Jonas
Oct 1, 2003·American Journal of Ophthalmology·Ingrid U ScottPhilip J Rosenfeld
Oct 1, 2003·American Journal of Ophthalmology·Ehud RechtmanMatthew A Speicher
Oct 15, 2003·Archives of Ophthalmology·Florian K P Sutter, Mark C Gillies
Nov 5, 2003·American Journal of Ophthalmology·Darius M MoshfeghiWilliam F Mieler
Nov 12, 2003·Archives of Ophthalmology·Jost B JonasRobert F Degenring
Oct 19, 2004·American Journal of Ophthalmology·Shishir AgrawalTrilok Prakash Agrawal

❮ Previous
Next ❯

Citations

Aug 7, 2008·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Suk Ho ByeonYong Sik Park
Jul 1, 2008·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Gi Jung ImHak Hyun Jung
Mar 8, 2007·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Igor KozakWilliam R Freeman
Apr 19, 2008·The British Journal of Ophthalmology·A M TammewarW R Freeman
Jun 1, 2008·Clinical Ophthalmology·Pier E Gallenga, Lucio Lobefalo
Jun 19, 2013·Survey of Ophthalmology·Weerawat KiddeeYvonne M Buys
Sep 2, 2015·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Akira WatanabeHiroshi Tsuneoka
Feb 3, 2007·Ophthalmology·Victoria L MorrisonWilliam R Freeman
Feb 23, 2010·American Journal of Ophthalmology·Ankur M ShahWilliam R Freeman
Sep 1, 2010·Therapeutic Delivery·Andrew L Lewis, Lisbeth Illum
Dec 15, 2015·Retina·Mostafa R AlamWilliam R Freeman
Apr 1, 2009·Retinal Cases & Brief Reports·Lee Teak TanMichael Lavin
Sep 14, 2017·Ophthalmic Surgery, Lasers & Imaging Retina·Ilkay Kilic MuftuogluWilliam R Freeman
Mar 20, 2019·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Irini ChatziralliPanagiotis Theodossiadis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here