Photoinduced electron transfer in folic acid investigated by ultrafast infrared spectroscopy.

The Journal of Physical Chemistry. B
Guifeng LiR Brian Dyer

Abstract

Conformational control of excited-state intramolecular electron transfer (ET) in folic acid (FA) has been investigated using femtosecond time-resolved infrared (TRIR) spectroscopy. Ultrafast excited-state ET between the pterin and the 4-aminobenzoyl subunits of FA is observed for the anionic form (at pH 10.0). An ET lifetime of 2.5 ps is estimated from Marcus theory for FA in the "U" conformation, in close agreement with the observed lifetime of 2.0 ps. Return to the ground state through the reverse ET reaction happens almost as rapidly, within 5 ps, resulting in rapid quenching of the singlet excited state. In mixed water:dimethyl sulfoxide solvent, ET becomes more unfavorable as FA adopts a more open conformation, thereby increasing the effective donor-acceptor distance and reducing the coupling energy. In contrast, no ET is observed for the cationic form of FA at low pH (6.0). In this case, the initial singlet excited state is localized on the pterin moiety of FA, and the excited-state charge distribution evolves with time. The charge redistribution in the pterin that occurs with intersystem crossing to the triplet state is characterized by changes in the transient IR spectrum. The excited-state lifetime is much longer in th...Continue Reading

References

Apr 30, 1976·The Journal of Organic Chemistry·P N Moorthy, E Hayon
Sep 25, 1992·Science·P O StoutlandW H Woodruff
Aug 1, 1973·European Journal of Biochemistry·C Thiéry
Jun 8, 2001·Free Radical Biology & Medicine·R JoshiT Mukherjee
May 7, 2002·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·A Sano, H Nakamura
Jul 18, 2002·Chemical Communications : Chem Comm·Julia A WeinsteinMichael W George
Feb 8, 2003·Archives of Biochemistry and Biophysics·Kazutaka HirakawaShosuke Kawanishi
Jul 15, 2003·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Andrés H ThomasEsther Oliveros
Aug 23, 2003·Chemical Communications : Chem Comm·Robert HuberHans-Achim Wagenknecht
Jan 22, 1962·Biochimica Et Biophysica Acta·M TSUBOIT SHIMANOUCHI
Mar 5, 2004·Journal of the American Chemical Society·Igor V RubtsovMichael J Therien
Nov 13, 2004·The Journal of Nutritional Biochemistry·Y I Kim
Mar 31, 2005·Annual Review of Physical Chemistry·Erik T J NibberingEhud Pines
Jun 21, 2005·Journal of Photochemistry and Photobiology. B, Biology·Morten Kristian OffJohan Moan
Oct 18, 2005·Photochemistry and Photobiology·Franco M CabrerizoEsther Oliveros
Jun 21, 2006·Accounts of Chemical Research·Carolina Lorente, Andrés H Thomas
Oct 13, 2006·The Journal of Physical Chemistry. B·Minako KondoStephen R Meech
Dec 22, 2006·The Journal of Physical Chemistry. a·Omar F MohammedEric Vauthey
Jul 17, 2007·The Journal of Physical Chemistry. a·Xing ChenZexing Cao
Sep 23, 2008·Vitamins and Hormones·Gerald Litwack
Apr 2, 2009·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·David A McGovernSusan J Quinn
Jun 17, 2009·The Journal of Physical Chemistry. B·Guifeng Li, Ksenija D Glusac

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Citations

Jan 22, 2014·Nature Communications·Guifeng LiR Brian Dyer
May 10, 2017·Physical Chemistry Chemical Physics : PCCP·R M DiScipioC E Crespo-Hernández
Jun 15, 2019·Progress in Biomaterials·Chinmay G HiremathMurigendra B Hiremath
Oct 30, 2020·Bioelectrochemistry·Abilene Rodrigues CorreiaValtencir Zucolotto
Jan 21, 2021·Proceedings of the National Academy of Sciences of the United States of America·Rachel KozlowskiR Brian Dyer
Jul 4, 2019·ACS Applied Materials & Interfaces·Chidinma G UgwujaEmmanuel I Unuabonah

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