Photoinduced interactions of supramolecular ruthenium(II) complexes with plasmid DNA: synthesis and spectroscopic, electrochemical, and DNA photocleavage studies

Inorganic Chemistry
Shawn SwaveyKaiyu Li

Abstract

Two new bridging ligands have been synthesized by combining substituted benzaldehydes with phenanthrolinopyrrole (php), resulting in new polyazine bridging ligands. The ligands have been characterized by (1)H NMR, mass spectroscopy, and elemental analysis. These new ligands display π-π* transitions above 500 nm with modest molar absorptivities. Upon excitation at the ligand-centered charge-transfer transition, weak emission with a maximum wavelength of 612 nm is observed. When coordinated to two ruthenium(II) bis(bipyridyl) groups, the new bimetallic complexes generated give an overall 4+ charge. The electronic transitions of the bimetallic ruthenium(II) complexes display traditional π-π* transitions at 287 nm and metal-to-ligand charge-transfer transitions at 452 nm with molar absorptivities greater than 30000 M(-1) cm(-1). Oxidation of the ruthenium(II) metal centers to ruthenium(III) occurs at potentials above 1.4 V versus the Ag/AgCl reference electrode. Spectroscopic and electrochemical measurements indicate that the ruthenium(II) moieties behave independently. Both complexes are water-soluble and show the ability to photonick plasmid DNA when irradiated with low-energy light above 550 nm. In addition, one of the complexes...Continue Reading

References

Apr 1, 1994·Journal of Photochemistry and Photobiology. B, Biology·M M FeeneyJ P Lecomte
Nov 5, 1997·Journal of Photochemistry and Photobiology. B, Biology·C MoucheronJ M Kelly
Apr 4, 2002·Journal of the American Chemical Society·Dennis J Hurley, Yitzhak Tor
Nov 9, 2004·Inorganic Chemistry·Tanya N Singh, Claudia Turro
Dec 8, 2004·Current Topics in Medicinal Chemistry·Enzo AlessioGianni Sava
Mar 1, 2005·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Fuyi WangPeter J Sadler
Mar 24, 2005·Journal of the American Chemical Society·Edith C GlazerYitzhak Tor
Oct 24, 2006·Inorganic Chemistry·Wee Han AngPaul J Dyson
Jun 19, 2007·Journal of the American Chemical Society·Edith C GlazerYitzhak Tor
Mar 14, 2008·Current Pharmaceutical Design·S PastorekovaJ Pastorek
Jul 4, 2008·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Soumya ChatterjeePaul J Dyson
Apr 7, 2009·Biochimie·Ana M Pizarro, Peter J Sadler
Aug 6, 2009·Dalton Transactions : an International Journal of Inorganic Chemistry·Katelitsa TriantafillidiAchilleas Garoufis
Jun 2, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Alberta Bergamo, Gianni Sava
Jun 18, 2011·Chemistry : a European Journal·Hai-Jun XuKnut Rurack
Aug 20, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Kathleen ServatyAndrée Kirsch-De Mesmaeker
Jun 7, 2012·Journal of the American Chemical Society·Willem VanderlindenSteven De Feyter
Oct 19, 2012·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Orsolya DömötörEva A Enyedy
Jul 25, 2013·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Eva IniguezRosa A Maldonado

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Citations

Dec 26, 2016·Journal of Inorganic Biochemistry·Dominique E WilliamsKathryn B Grant
Jun 24, 2018·Applied Biochemistry and Biotechnology·Nasima Arshad, Shahid Iqbal Farooqi
Oct 21, 2016·Chemistry : a European Journal·Sushma B SinghAyesha Khan
Dec 5, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bruno F O NascimentoTeresa M V D Pinho E Melo
Jul 14, 2018·Applied Biochemistry and Biotechnology·Pankajkumar A VekariyaMohan N Patel

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