Photoinduced reactions of cis,trans,cis-[Pt(IV)(N3)2(OH)2(NH3)2) with 1-methylimidazole.

Chemistry : a European Journal
Hazel I A PhillipsPeter J Sadler

Abstract

The photodecomposition of cis,trans,cis-[Pt(IV)(N(3))(2)(OH)(2)(NH(3))(2)] in phosphate buffered saline (PBS), as well as in the presence of 1-methylimidazole (1-MeIm), induced by UVA light (centred at lambda=365 nm) has been studied by multinuclear NMR spectroscopy. We show that photoreduction, photoisomerisation and trans-labilisation pathways are involved. The photodecomposition pathway in PBS, which involves azide release, as detected by (14)N NMR spectroscopy, appears to differ from that in acidic aqueous conditions, under which N(2) is a product. A number of trans-{N-Pt(II)-NH(3)} species were also observed as photoproducts, as well as the release of free ammonia with a corresponding increase in pH. Oxygen was also detected as a product in solution. In the presence of 1-methylimidazole, surprisingly the major photoproduct was the tetra-substituted Pt(II) complex [Pt(II)(1-MeIm-N(3))(4)](2+) (structure confirmed by crystallography), even at a Pt/1-MeIm molar ratio of 1:1, together with cis- and trans-[Pt(II)(NH(3))(2)(1-MeIm-N(3))(2)](2+) as minor products. In these photoinduced 1-MeIm reactions, free ammonia, azide and oxygen were also detected. The results from this study illustrate that photoinduced reactions of platinu...Continue Reading

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Citations

Apr 7, 2009·Biochimie·Ana M Pizarro, Peter J Sadler
Jul 12, 2017·Dalton Transactions : an International Journal of Inorganic Chemistry·Anton A ShushakovEvgeni M Glebov
Sep 17, 2011·Chemistry : a European Journal·Nicola J FarrerPeter J Sadler
Sep 20, 2011·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Rene L JohnsonWilliam H Casey
Dec 22, 2009·Dalton Transactions : an International Journal of Inorganic Chemistry·Nicola J FarrerPeter J Sadler
Dec 4, 2009·Archiv der Pharmazie·Pedro O Miranda, Lise-Lotte Gundersen
Aug 18, 2010·Chemistry : a European Journal·Christophe LoupGeneviève Pratviel
Aug 19, 2010·Chemical Communications : Chem Comm·Daniel CrespyAlexander Schiller
Jul 17, 2019·Angewandte Chemie·Cinzia ImbertiPeter J Sadler
Jul 19, 2012·Chemistry : a European Journal·Hui-Chung TaiRobert J Deeth
Sep 18, 2009·Dalton Transactions : an International Journal of Inorganic Chemistry·Teresa GianferraraEnzo Alessio
Apr 5, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Aron F WestendorfPatrick J Bednarski
Nov 16, 2010·Dalton Transactions : an International Journal of Inorganic Chemistry·Luca Ronconi, Peter J Sadler
Jun 28, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Dongfang ZhouYubin Huang
Jun 28, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Alexander Yu Sokolov, Henry F Schaefer
Dec 10, 2009·Chemical Research in Toxicology·Nicola J FarrerPeter J Sadler
May 20, 2021·The Journal of Physical Chemistry Letters·Leon Freitag, Leticia González
Sep 6, 2012·Inorganic Chemistry·Justin J Wilson, Stephen J Lippard
Jul 30, 2011·Journal of the American Chemical Society·Flavia BarragánVicente Marchán

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