Photoinduced Specific Acylation of Phenolic Hydroxy Groups with Aldehydes

Angewandte Chemie
Tairin KawasakiMasahiro Murakami

Abstract

A convenient method is reported to specifically acylate phenolic hydroxyl groups through a radical pathway. When a mixture of an aldehyde and a phenol in ethyl acetate is irradiated with blue light in the presence of iridium and nickel bromide catalysts at ambient temperature, phenoxyl and acyl radicals are transiently generated in situ and cross-couple to furnish an ester. Aliphatic hydroxy groups remain untouched under the reaction conditions.

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Citations

Oct 31, 2020·Journal of the American Chemical Society·Xiaomin ShuHaohua Huo
Jun 12, 2021·Nature Communications·Leitao HuanHaohua Huo
Aug 1, 2021·Chemistry, an Asian Journal·Chandrasekaran Sivaraj, Thirumanavelan Gandhi

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