Photolability of bleomycin and its complexes

Cancer Letters
N Thakrar, K T Douglas

Abstract

Bleomycin has been found to be very sensitive to photolysis and on irradiation with the full spectral range of a medium-pressure mercury lamp undergoes a number of photo-induced reactions; there is a process in which the absorbance at 310 nm decreases, and a slower process in which it increases with photolysis time. The faster process can be studied by irradiation at approximately 300-350 nm, is complete in approximately 8 min, obeys first order kinetics, but is itself biphasic. The Fe(II) and Cu(II) complexes of bleomycin are also photolabile, as is the bleomycin-DNA complex.

References

Jan 1, 1980·Advances in Enzyme Regulation·A P Grollman, M Takeshita

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Citations

Jan 1, 1990·Chemico-biological Interactions·D H PeteringW E Antholine
Apr 1, 1985·Photochemistry and Photobiology·W E AntholineD H Petering
Oct 12, 1990·Journal of Chromatography·U R Tjaden, E A de Bruijn
May 10, 1985·Journal of Chromatography·S Eksborg, H Ehrsson
Apr 15, 1983·Biochemical and Biophysical Research Communications·H A Ratwatte, K T Douglas

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