Photoluminescent Hybrids of Cellulose Nanocrystals and Carbon Quantum Dots as Cytocompatible Probes for in Vitro Bioimaging

Biomacromolecules
Jiaqi GuoOrlando J Rojas

Abstract

We present an approach to construct biocompatible and photoluminescent hybrid materials comprised of carbon quantum dots (CQDs) and TEMPO-oxidized cellulose nanocrystals (TO-CNCs). First, the amino-functionalized carbon quantum dots (NH2-CQDs) were synthesized using a simple microwave method, and the TO-CNCs were prepared by hydrochloric acid (HCl) hydrolysis followed by TEMPO-mediated oxidation. The conjugation of NH2-CQDs and TO-CNCs was conducted via carbodiimide-assisted coupling chemistry. The synthesized TO-CNC@CQD hybrid nanomaterials were characterized using X-ray photoelectron spectroscopy, cryo-transmittance electron microscopy, confocal microscopy, and fluorescence spectroscopy. Finally, the interactions of TO-CNC@CQD hybrids with HeLa and RAW 264.7 macrophage cells were investigated in vitro. Cell viability tests suggest the surface conjugation with NH2-CQDs not only improved the cytocompatibility of TO-CNCs, but also enhanced their cellular association and internalization on both HeLa and RAW 264.7 cells after 4 and 24 h incubation.

References

Jun 18, 2002·Nature·Silvano De Franceschi, Leo Kouwenhoven
Oct 8, 2004·Journal of the American Chemical Society·Xiaoyou XuWalter A Scrivens
Dec 1, 2004·Langmuir : the ACS Journal of Surfaces and Colloids·Tekla TammelinPer Stenius
Mar 15, 2005·Biomacromolecules·Stephanie Beck-CandanedoDerek G Gray
Apr 13, 2006·Nano Letters·B Devika ChithraniWarren C W Chan
Jun 15, 2006·Journal of the American Chemical Society·Ya-Ping SunSu-Yuan Xie
Oct 24, 2007·Journal of the American Chemical Society·Shuping Dong, Maren Roman
Feb 11, 2009·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Paresh Chandra RayPeter P Fu
Apr 8, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Christian AulinLars Wågberg
Oct 6, 2009·Advanced Materials·Haeshin LeePhillip B Messersmith
Oct 22, 2009·Small·Ayush Verma, Francesco Stellacci
Mar 6, 2010·Chemical Reviews·Youssef HabibiOrlando J Rojas
Oct 6, 2010·ACS Applied Materials & Interfaces·Khaled A MahmoudJohn H T Luong
May 14, 2011·Chemical Society Reviews·Robert J MoonJeff Youngblood
May 21, 2011·Angewandte Chemie·Dieter KlemmAnnie Dorris
Dec 16, 2011·Chemical Society Reviews·Shahriar SharifiMorteza Mahmoudi
Mar 13, 2012·Trends in Biotechnology·Edmond LamJohn H T Luong
Aug 16, 2012·Accounts of Chemical Research·Motao ZhuYuliang Zhao
Jan 25, 2014·Biomacromolecules·Karoliina JunkaOrlando J Rojas
Feb 19, 2014·Journal of the American Chemical Society·Alesja IvanovaThomas Bein
May 27, 2014·Colloids and Surfaces. B, Biointerfaces·Zahid HanifSoong Ho Um
Jun 11, 2014·Biomacromolecules·Rui M A DominguesRui L Reis
Jul 12, 2014·Accounts of Chemical Research·Candace C Fleischer, Christine K Payne
Aug 6, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·T AlejoM M Velázquez
Sep 27, 2014·Environmental and Molecular Mutagenesis·Julia CatalánHannu Norppa
Oct 14, 2014·Chemical Society Reviews·Chao ShenXiaogang Liu
Oct 16, 2014·Chemical Society Reviews·Shi Ying LimZhiqiang Gao
Oct 24, 2014·ACS Applied Materials & Interfaces·Vaishakhi MohantaSatish Patil
Mar 17, 2015·Biomacromolecules·Julien R G NavarroLennart Bergström
Apr 28, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Pengju G LuoYa-Ping Sun

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Citations

Jan 10, 2018·Angewandte Chemie·Shanyu ZhaoGustav Nyström
Mar 6, 2018·Advanced Materials·Eero KontturiOlli Ikkala
Jun 3, 2020·Advanced Materials·Wei LiShouxin Liu
Oct 1, 2020·Advanced Science·Ting-You LiJr-Hau He
Feb 14, 2018·Dalton Transactions : an International Journal of Inorganic Chemistry·Jayasmita JanaTarasankar Pal
Dec 8, 2020·Biomacromolecules·Sebastian RajaAntonio Sechi
Feb 23, 2020·Advances in Colloid and Interface Science·Milad AshrafizadehAbbas Pardakhty
Jun 30, 2021·ACS Sensors·Kelcilene B R TeodoroDaniel S Correa
Jul 19, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Tianyang LengLinda J Johnston
Oct 27, 2021·Advanced Materials·Joice Jaqueline KaschukJaana Vapaavuori

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