Photoluminescent Peptide-Based Nanostructures as FRET Donor for Fluorophore Dye

Chemistry : a European Journal
Carlo DiaferiaAntonella Accardo

Abstract

A great interest has been recently generated by the discovery that peptide-based nanostructures (NSs) endowed with cross-β structure may show interesting photoluminescent (PL) properties. It was shown that NSs formed by PEGylated hexaphenylalanine (PEG8-F6, PEG=polyethylene glycol) are able to emit at 460 nm when excited at 370 or 410 nm. Here, the possibility to transfer the fluorescence of these PEG8-F6-based NSs by foster resonance electron transfer (FRET) phenomenon to a fluorescent dye was explored. To achieve this aim, the 4-chloro-7-nitrobenzofurazan (NBD) dye was encapsulated in these NSs. Structural data in solution and in solid state, obtained by a variety of techniques (circular dichroism, Fourier-transform infrared spectroscopy, wide-angle X-ray scattering, and small-angle X-ray scattering), indicated that the organization of the peptide spine of PEG8-F6 NS, which consists of anti-parallel β-sheets separated by a dry interface made of interacting phenylalanine side chains, was maintained upon NBD encapsulation. The spectroscopic characterization of these NSs clearly showed a red-shift of the emission fluorescence peak both in solution and in solid state. This shift from 460 to 530 nm indicated that a FRET phenomenon...Continue Reading

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Citations

Mar 16, 2018·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Carlo DiaferiaAntonella Accardo
Jan 3, 2019·Soft Matter·Carlo DiaferiaAntonella Accardo
Aug 6, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Carlo DiaferiaAntonella Accardo
Oct 1, 2019·Chemistry : a European Journal·Concetta AvitabileAlessandra Romanelli
Jan 24, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Diego TesauroFilomena Rossi
Sep 24, 2019·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Carlo DiaferiaAntonella Accardo
Mar 23, 2019·Journal of Peptide Science : an Official Publication of the European Peptide Society·Boris ApterGil Rosenman
Mar 18, 2021·Chemical Communications : Chem Comm·Alessandra MontiNunzianna Doti
Sep 9, 2021·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Carlo DiaferiaAntonella Accardo

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