Photolysis of atorvastatin in aquatic environment: Influencing factors, products, and pathways

Chemosphere
Mengjie WangShixiang Gao

Abstract

Atorvastatin (ATV), a second generation cholesterol-lowering drug, is detected frequently in natural water because of its extensive use and incomplete removal from wastewater. In this study, the photochemical behavior of ATV under simulated solar irradiation was systematically investigated in order to assess the potential of photolysis as its transformation pathway in aquatic environment. The quantum yield of ATV direct photolysis was determined to be 0.0041. Among various water components investigated, including pH, Suwannee River Fulvic Acid (SRFA), Fe3+, HCO3-, SO42- and NO3-, the major factors contributing to the indirect photolysis of ATV were SRFA and NO3-, and the co-existence of SRFA and NO3- showed no interaction in synthetic water containing the above water components. The results were further verified in natural water samples. Singlet oxygen (1O2) played dominant role in the indirect photolysis of ATV, and the contributions of 1O2 and ·OH to the photolysis of ATV in the solution with optimum combination of water components were calculated to be 67.14% and 0.66%, respectively. Nine phototransformation intermediates were identified by liquid chromatography - time-of-flight - mass spectrometry (LC-TOF-MS), and the degra...Continue Reading

Citations

Apr 9, 2020·Environmental Science and Pollution Research International·Taise PerondiTiciane Sauer Pokrywiecki
Oct 21, 2020·Water Science and Technology : a Journal of the International Association on Water Pollution Research·T PerondiT S Pokrywiecki
Dec 30, 2020·Journal of Hazardous Materials·Hanyu WangShixiang Gao
Jun 25, 2021·Environmental Science and Pollution Research International·Senwen PingYuan Ren
Jul 30, 2021·Scientific Reports·Madalina OpricaMihaela Baibarac
Aug 11, 2021·Environmental Science. Processes & Impacts·Martina BiošićSandra Babić
Nov 11, 2021·Environmental Science & Technology·Xiaowei WuShixiang Gao

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