Photomodulation of DNA-Templated Supramolecular Assemblies

Chemistry : a European Journal
Jenifer Rubio-MagnietoMathieu Surin

Abstract

A new type of DNA ligand that contains a phosphate-binding group and a photoresponsive azobenzene moiety is reported. When the azobenzene is in trans configuration, the ligand binds to the minor groove of a double-stranded DNA, whereas it partially desorbs upon trans-cis isomerisation with light. The ability to photoswitch the ligand upon interaction with DNA is evidenced by (chir)optical signatures, and deciphered by the differences of binding geometry, stability, and dynamics of the DNA/ligand complexes for the two isomers. We exploit these properties to photomodulate DNA-templated self-assembly, through the incorporation of another π-stacking DNA ligand, which together with the photoresponsive ligand form mixed supramolecular complexes along DNA. Our study demonstrates that well-designed photoresponsive DNA binders can be used to modulate multicomponent supramolecular DNA assemblies.

References

Jul 10, 2003·Chemical Reviews·Christophe Dugave, Luc Demange
Jul 11, 2006·Angewandte Chemie·Günter Mayer, Alexander Heckel
Sep 15, 2006·Chembiochem : a European Journal of Chemical Biology·Elena A GounPaul A Wender
Jan 25, 2007·Molecular BioSystems·XinJing Tang, Ivan J Dmochowski
Jan 1, 2008·Advanced Drug Delivery Reviews·Paul A WenderThomas H Pillow
Aug 14, 2008·Journal of the American Chemical Society·Johanna AnderssonJoakim Andréasson
Jan 27, 2009·Chemical Society Reviews·Héctor A Becerril, Adam T Woolley
Apr 28, 2009·Chemistry : a European Journal·Sébastien Ulrich, Jean-Marie Lehn
Sep 17, 2009·Angewandte Chemie·Pim G A JanssenAlbertus P H J Schenning
Nov 12, 2010·Chemical Communications : Chem Comm·Amparo Ruiz-CarreteroAlbertus P H J Schenning
Feb 22, 2011·Chemical Communications : Chem Comm·Amparo Ruiz-CarreteroAlbertus P H J Schenning
Apr 13, 2011·Chemical Society Reviews·Andrew A Beharry, G Andrew Woolley
Sep 9, 2011·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Evelyne SageStefania Francesconi
Oct 20, 2011·Chemical Society Reviews·H M Dhammika Bandara, Shawn C Burdette
Oct 21, 2011·Chemical Society Reviews·Christopher K McLaughlinHanadi F Sleiman
Mar 20, 2012·Chemical Reviews·Yin Nah Teo, Eric T Kool
May 24, 2012·Chemical Society Reviews·Xuzhou YanFeihe Huang
Aug 1, 2012·Proceedings of the National Academy of Sciences of the United States of America·Erika I GeihePaul A Wender
Apr 26, 2013·Chemical Reviews·Wiktor SzymańskiBen L Feringa
May 15, 2013·Journal of the American Chemical Society·Yunqi YanDavid S Ginger
Jun 19, 2013·Journal of the American Chemical Society·Charlotte GehinHoward Riezman
Jul 9, 2013·Nanoscale·Eric BusseronNicolas Giuseppone
Sep 21, 2013·Advanced Materials·Zhen-Gang Wang, Baoquan Ding
Jan 25, 2014·Chemistry : a European Journal·Gevorg SargsyanMilan Balaz
Feb 8, 2014·ACS Nano·Esha SenguptaDavid S Ginger
Apr 10, 2014·Journal of the American Chemical Society·Scott M D WatsonAndrew Houlton
Jul 17, 2014·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Xing FangTomoe Negishi
Oct 7, 2014·Chemical Communications : Chem Comm·Delphine PaolantoniSébastien Ulrich
Jan 15, 2015·Angewandte Chemie·Jean-Marie Lehn
Feb 11, 2015·International Journal of Molecular Sciences·Delphine PaolantoniSébastien Ulrich
Feb 24, 2015·Chemical Communications : Chem Comm·Daria V BerdnikovaHeiko Ihmels
May 15, 2015·Chemistry : a European Journal·Josipa BrglezChristof M Niemeyer
Jul 17, 2015·Angewandte Chemie·Eline BartolamiSébastien Ulrich
Apr 1, 2016·Biomacromolecules·Selina SchimkaMark Santer
Apr 22, 2016·Angewandte Chemie·Juan M PriegueJavier Montenegro
Jul 14, 2016·Journal of the American Chemical Society·Yusuke NakasoneMasahide Terazima
Nov 15, 2016·Chemical Communications : Chem Comm·Jenifer Rubio-MagnietoMathieu Surin
Feb 23, 2017·Chemistry : a European Journal·Nasreddine KanfarJean-Yves Winum
Aug 18, 2017·Chemistry : a European Journal·Eline BartolamiSébastien Ulrich
Sep 30, 2017·Chemistry : a European Journal·Wojciech DrożdżSébastien Ulrich

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved