Photonic ring resonance is a versatile platform for performing multiplex immunoassays in real time

Journal of Immunological Methods
Sasi MudumbaRufus W Burlingame

Abstract

Photonic ring resonance is a property of light where in certain circumstances specific wavelengths are trapped in a ring resonator. Sensors based on silicon photonic ring resonators function by detecting the interaction between light circulating inside the sensor and matter deposited on the sensor surface. Binding of biological material results in a localized change in refractive index on the sensor surface, which affects the circulating optical field extending beyond the sensor boundary. That is, the resonant wavelength will change when the refractive index of the medium around the ring resonator changes. Ring resonators can be fabricated onto small silicon chips, allowing development of a miniature multiplex array of ring based biosensors. This paper describes the properties of such a system when responding to the refractive index changed in a simple and precise way by changing the ionic strength of the surrounding media, and in a more useful way by the binding of macromolecules to the surface above the resonators. Specifically, a capture immunoassay is described that measures the change of resonant wavelength as a patient serum sample with anti-SS-A autoantibodies is flowed over a chip spotted with SS-A antigen and amplified...Continue Reading

Citations

Dec 9, 2020·Science Translational Medicine·Delphine SterlinGuy Gorochov
Jan 7, 2020·Current Opinion in Environmental Science & Health·Maria C Cardenosa-RubioRyan C Bailey
Apr 29, 2021·PloS One·Sachie IkegamiThomas J Gniadek
Dec 30, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Huan ZhangHongda Chen

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