Photoperiod regulates lean mass accretion, but not adiposity, in growing F344 rats fed a high fat diet

PloS One
A W RossPeter J Morgan

Abstract

In this study the effects of photoperiod and diet, and their interaction, were examined for their effects on growth and body composition in juvenile F344 rats over a 4-week period. On long (16L:8D), relative to short (8L:16D), photoperiod food intake and growth rate were increased, but percentage adiposity remained constant (ca 3-4%). On a high fat diet (HFD), containing 22.8% fat (45% energy as fat), food intake was reduced, but energy intake increased on both photoperiods. This led to a small increase in adiposity (up to 10%) without overt change in body weight. These changes were also reflected in plasma leptin and lipid levels. Importantly while both lean and adipose tissue were strongly regulated by photoperiod on a chow diet, this regulation was lost for adipose, but not lean tissue, on HFD. This implies that a primary effect of photoperiod is the regulation of growth and lean mass accretion. Consistent with this both hypothalamic GHRH gene expression and serum IGF-1 levels were photoperiod dependent. As for other animals and humans, there was evidence of central hyposomatotropism in response to obesity, as GHRH gene expression was suppressed by the HFD. Gene expression of hypothalamic AgRP and CRH, but not NPY nor POMC, ...Continue Reading

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Citations

Jul 15, 2017·Chronobiology International·Xiaoxian XieZhengwei Fu
Nov 18, 2017·International Journal of Molecular Sciences·Mounir ChennaouiDanielle Gomez-Merino
Jun 23, 2018·Journal of Animal Physiology and Animal Nutrition·Nick John CaveDavid Granville Thomas
Dec 27, 2018·Journal of Neuroendocrinology·Gisela HelferPeter J Morgan
Aug 10, 2016·The Journal of Comparative Neurology·Gábor WittmannRonald M Lechan

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Methods Mentioned

BETA
environmental stresses
PCR
ELISA
genetic knock-outs

Software Mentioned

Sigma Plot
Genstat
Systat
ImagePro Plus

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