Photophysical properties of clozapine and determination of its concentration by using Eu(III)-dipicolinic acid complex as photo probe

Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Esam Bakir

Abstract

Clozapine drug is photo-stable under irradiation of light for a long time, so we can store it in difficult and hot conditions. In addition the activity of clozapine is inhibited of the absorption spectra in the presence of glucose and enhanced in the presence of iron(III). We succeeded in detecting the concentration of clozapine in the range 1-60x10(-9)M using Eu(III)-dipicolinic acid complex as photo probe type and using Stern-Völmer equation to determine the Stern-Völmer constant, critical radius and the mechanism of quenching of luminescence of Eu(III)-dipicolinic acid complex is found to be of dipolar-dipolar interaction.

References

Jun 30, 2004·CNS Drugs·Bruce J KinonPeter F Buckley

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Citations

Dec 14, 2011·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Yufeng ChenXiaojing Yang

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