Photophysical properties, singlet oxygen generation efficiency and cytotoxic effects of aloe emodin as a blue light photosensitizer for photodynamic therapy in dermatological treatment

Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology
Lixin ZangPeisong Meng

Abstract

Conventional photodynamic therapy (PDT) uses red light for deeper penetration. A natural compound, aloe emodin (AE) with anticancer and photosensitising capabilities, excited by blue light, is proposed to treat superficial diseases. The photophysical properties and singlet oxygen quantum yield (ΦΔ) of AE, as well as the cytotoxic effects of AE on human cells, were investigated. The absorption and emission spectra of AE were analyzed. The ΦΔ of AE was measured by a relative method. In order to study the relationship between ΦΔ and the oxygen concentration, the dependence of ΦΔ on the oxygen concentration was investigated. The cytotoxic effects of AE alone and AE-mediated PDT were compared. The relationship between cells' survival rate and PDT conditions was studied. According to spectral analysis, the energy levels of AE were identified. The maximum absorption peak of AE is in the blue region, which makes AE-mediated PDT suitable for superficial diseases. The ΦΔ of AE was determined to be 0.57(2), which was found to be dependent on the oxygen concentration. The studies under low oxygen concentration proved that there is no type I reaction between AE and the probe for singlet oxygen detection. The effect of AE-mediated PDT was si...Continue Reading

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Citations

Nov 5, 2019·Phytotherapy Research : PTR·Xiaoxv DongJian Ni
Apr 2, 2020·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Wenpeng MaXiaoyan Zeng
Mar 20, 2021·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Bianka Siewert
Dec 4, 2020·Journal of Photochemistry and Photobiology. B, Biology·María Laura MugasAdriana Casas
Jul 29, 2021·Journal of Microbiology and Biotechnology·Woodvine OtienoYanhong Ji

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