Photopic electroretinograms of mGluR6-deficient mice

Current Eye Research
Toshiyuki KoyasuHiroko Terasaki

Abstract

To study the properties of the photopic electroretinograms (ERGs) of the metabotropic glutamate receptor subtype 6 (mGluR6)-deficient mice and to investigate the contribution of cone ON-and OFF-pathways to the mouse photopic ERGs. Photopic ERGs were recorded from mGluR6-deficient and wild-type mice. Photopic ERGs were also recorded after an intravitreous injection of cis-2,3 piperidine dicarboxylic acid (PDA) to block the transmission of signals from the photoreceptors to the OFF-bipolar cells, horizontal cells, and other inner retinal neurons. The amplitude of the b-wave of the photopic ERG was severely reduced in mGluR6-deficient mice, but a small, slow, positive component was seen after the a-wave. Intravitreous injection of PDA eliminated this positive component. The mGluR6-deficient mouse is a useful animal model to study the contribution of the ON-and OFF-pathways to the mouse ERG.

References

Mar 1, 1992·Trends in Neurosciences·P H Schiller
Nov 12, 1993·Neuroscience Letters·N S PeacheyM I Naash
Mar 1, 1996·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·D C Hood, D G Birch
Jul 1, 1997·Visual Neuroscience·N Vardi, K Morigiwa
Nov 14, 1997·Neuroscience Letters·H SugiharaY Fukuda
Oct 26, 1999·Trends in Neurosciences·L T Sharpe, A Stockman
Jan 11, 2002·Journal of Neurophysiology·Vivek R KrishnaNeal S Peachey
Nov 28, 2002·The Journal of Comparative Neurology·Willem KamphuisFrederike Dijk
Aug 9, 2003·Documenta Ophthalmologica. Advances in Ophthalmology·Neal S Peachey, Sherry L Ball
Mar 23, 2005·Proceedings of the National Academy of Sciences of the United States of America·Thaddeus P DryjaAruna S Rajagopalan
Jul 12, 2005·Experimental Eye Research·Shinji UenoYozo Miyake
Oct 26, 2005·Vision Research·Yoshiki UedaYoshinori Shichida
Dec 8, 2005·Visual Neuroscience·Sumit SharmaNeal S Peachey
Jun 8, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yoshihiko TsukamotoYutaka Fukuda

❮ Previous
Next ❯

Citations

Sep 18, 2010·Cell Calcium·Chieko KoikeTakahisa Furukawa
Apr 7, 2010·Progress in Retinal and Eye Research·Enrica StrettoiDevid Damiani
Feb 23, 2010·Neuroscience Letters·Masaki Sato, Teruya Ohtsuka
Mar 3, 2009·Experimental Eye Research·Gen MiuraLaura J Frishman
Apr 29, 2008·Experimental Eye Research·Suguru ShiratoLaura J Frishman
Aug 25, 2020·British Journal of Pharmacology·Annette E AllenWilliam S Redfern
Jun 8, 2013·Documenta Ophthalmologica. Advances in Ophthalmology·Tomomi HaradaDaijiro Kurosaka
Apr 14, 2021·Developmental Biology·Courtney A BurgerMelanie A Samuel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Investigative Ophthalmology & Visual Science
Mineo KondoHiroko Terasaki
The British Journal of Ophthalmology
S YamamotoK Kawasaki
Investigative Ophthalmology & Visual Science
S NusinowitzJohn R Heckenlively
Investigative Ophthalmology & Visual Science
M KondoHiroko Terasaki
© 2021 Meta ULC. All rights reserved