Photoplethysmography for non-invasive in vivo measurement of bone hemodynamics

Physiological Measurement
Jaime Mateus, Alan R Hargens

Abstract

Developments in photoplethysmography (PPG) hardware make this device a promising tool for non-invasive deep-tissue hemodynamic measurements. The aim of this study was to validate the use of PPG as a tool for non-invasive bone hemodynamic measurements. A new PPG device capable of measuring bone hemodynamic responses was designed, tested and validated. Validation experiments included cold exposure, arterial occlusion, skin occlusion and nitroglycerin exposure. Cold exposure resulted in a decrease in skin perfusion (p = 0.011) and bone perfusion (p = 0.005); arterial occlusion also resulted in decreased skin perfusion (p < 0.001) and bone perfusion (p = 0.008), with arterial occlusion resulting in a greater decrease in perfusion than cold exposure. The independence of the skin and bone PPG signals was demonstrated by the ability to independently increase (p = 0.003) and decrease (p = 0.005) the skin signal without significantly affecting the bone signal. Our experiments build upon and expand previous PPG developments and validation studies. Our custom-made PPG hardware represents a state-of-the-art tool for non-invasive monitoring of deep tissues, and our data support the use of PPG as a valid tool for measuring bone hemodynamic r...Continue Reading

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Citations

Jun 15, 2013·Vascular Health and Risk Management·Pichitra Uangpairoj, Masahiro Shibata
Oct 1, 2013·Applied Ergonomics·Sae Hoon KimAlan R Hargens
Apr 20, 2014·Physiological Reports·Armando Rosales-VelderrainAlan R Hargens
Nov 22, 2012·Bone·Jaime Mateus, Alan R Hargens
Jul 25, 2015·Journal of Physiological Anthropology·Tiziano Binzoni, Lorenzo Spinelli
Jul 1, 2017·Journal of Applied Physiology·Michelle HowdenAlan R Hargens
Oct 12, 2018·Journal of Biophotonics·Joakim GlasinDaniel Wilhelms
Jun 6, 2014·Physiological Measurement·Parisa FarzamTurgut Durduran
Sep 6, 2017·The Journal of Bone and Joint Surgery. American Volume·Sravya T ChallaBrandon R Macias
May 2, 2015·Journal of Applied Physiology·Jamila H SiamwalaAlan R Hargens
Jul 19, 2013·Physiological Measurement·Parisa FarzamTurgut Durduran
Feb 26, 2019·Journal of Clinical Monitoring and Computing·Erik NäslundRobert Frithiof
May 5, 2018·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Robert MeertensWilliam David Strain

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