Photoprotection by dietary phenolics against melanogenesis induced by UVA through Nrf2-dependent antioxidant responses

Redox Biology
Anyamanee ChaiprasongsukUraiwan Panich

Abstract

Dietary phenolics may play a protective role in UV-mediated skin pigmentation through their antioxidant and UV-absorbing actions. In this study, we investigated whether genetic silencing of Nrf2, regulating the transcription of antioxidant genes, affected melanogenesis in primary human epidermal melanocytes (HEMn) and B16F10 melanoma cells subjected to UVA (8J/cm(2)) exposure. Then, we explored the antimelanogenic actions of phenolics; caffeic acid (CA) and ferulic acid (FA) providing partial UVA protection; quercetin (QU) and rutin (RU) providing strong UVA protection and; avobenzone (AV), an efficient UVA filter, in association with modulation of Nrf2-mediated antioxidant defenses in response to UVA insults in B16F10 cells. Upon oxidative insults, Nrf2 silencing promoted melanogenesis in both HEMn and B16F10 cells irradiated with UVA. Stimulation of melanogenesis by UVA correlated with increased ROS and oxidative DNA damage (8-OHdG), GSH depletion as well as a transient downregulation of Nrf2 nuclear translocation and of Nrf2-ARE signaling in B16F10 cells. All test compounds exerted antimelanogenic effects with respect to their abilities to reverse UVA-mediated oxidative damage as well as downregulation of Nrf2 activity and i...Continue Reading

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Citations

Feb 18, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Oludemi TaofiqIsabel C F R Ferreira
Apr 17, 2017·Redox Biology·Agnieszka GęgotekElżbieta Skrzydlewska
May 13, 2017·Free Radical Biology & Medicine·Saowanee JeayengUraiwan Panich
Jan 5, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yan WangZhen Yang
Dec 25, 2016·The Journal of Pharmacology and Experimental Therapeutics·Anyamanee ChaiprasongsukUraiwan Panich
Mar 4, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ramona FigatAgnieszka Pietrosiuk
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Methods Mentioned

BETA
nuclear translocation
Transfection
Protein Assay
flow
fluorescence activated cell sorter
PCR
Assay
ELISA

Software Mentioned

GraphPad
Image
Prism
Primer Express

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