Photoprotection of Cerium Oxide Nanoparticles against UVA radiation-induced Senescence of Human Skin Fibroblasts due to their Antioxidant Properties

Scientific Reports
Yaxi LiYanqun Liu

Abstract

Ultraviolet (UV) irradiation, particularly ultraviolet A (UVA), stimulates reactive oxygen species (ROS) production in the epidermis and dermis, which plays a major part in the photoageing of human skin. Several studies have demonstrated that cerium oxide nanoparticles (CeO2 NP) can exhibit an antioxidant effect and free radical scavenging activity. However, the protective role of CeO2 NP in skin photoageing and the underlying mechanisms are unclear. In this study, we investigated the effects of CeO2 NP on UVA-irradiated human skin fibroblasts (HSFs) and explored the potential signalling pathway. CeO2 NP had no apparent cytotoxicity, and could reduce the production of proinflammatory cytokines, intracellular ROS, senescence-associated β-galactosidase activity, and downregulate phosphorylation of c-Jun N-terminal kinases (JNKs) after exposure to UVA radiation. Based on our findings, CeO2 NPs have great potential against UVA radiation-induced photoageing in HSFs via regulating the JNK signal-transduction pathway to inhibit oxidative stress and DNA damage.

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Citations

Apr 30, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Alexander MorlandoKonstantin Konstantinov
Aug 29, 2020·Journal of Cosmetic Dermatology·Érika Minuci NeryAndré Rolim Baby
Jan 5, 2020·AAPS PharmSciTech·V T P FerreiraP M B G Maia Campos
Dec 15, 2020·Oxidative Medicine and Cellular Longevity·P Veeramani KandanNagarajan Rajendra Prasad
Sep 26, 2019·ACS Applied Materials & Interfaces·Prashanth K B NageshMurali M Yallapu
Aug 24, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Eshant BhatiaRinti Banerjee
Jan 14, 2020·Chemical Research in Toxicology·Veronica Montesinos-CruzRodrigo Franco

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Methods Mentioned

BETA
transmission electron microscopy
Fluorescence
ELISAs
ELISA
PCR
Protein Assay
Infrared Imaging

Software Mentioned

SPSS

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