Photoprotection or photodamage: a direct observation of nonradiative dynamics from 2-ethylhexyl 4-dimethylaminobenzoate sunscreen agent

Physical Chemistry Chemical Physics : PCCP
Chensheng MaWai-Ming Kwok

Abstract

Apart from being an analogue of the prototype for photoinduced intramolecular charge transfer (ICT), 2-ethylhexyl 4-dimethylaminobenzoate (EHDMABA) is also one of the earliest patented and most commonly used sunscreen components. There is, however, little documented information about the photophysics and factors affecting the photophysics of this molecule. Such information is of importance for both the understanding of the ICT reaction and assessing the underlying process of photoprotection, especially in view of the "sunscreen controversy" that has arisen from the contrasting in vivo vs. in vitro photobiological results on this and related UV filters. We report herein a femtosecond broadband time-resolved fluorescence (fs-TRF), complemented by transient absorption (fs-TA) to allow a full probe of the excited state cascades for EHDMABA and two of its derivatives in solvents of varied properties. The results provide direct evidence for a nearly solvent independent inner sphere ICT reaction occurring on the sub-picosecond time scale, and an ensuing solvent dictated deactivation of the ICT state. The ICT state in the aprotic solvent acetonitrile decayed solely through the intrinsic intersystem crossing (ISC) to produce a potential...Continue Reading

References

May 1, 1992·Photochemistry and Photobiology·A A ShawM D Shetlar
Oct 1, 1991·The Journal of Investigative Dermatology·V E ReeveR D Ley
Jan 1, 1990·Archives of Dermatological Research·H Flindt-HansenT E Larsen
Mar 29, 2003·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Nick SerponeJincai Zhao
Mar 29, 2003·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Rajeshwar P Sinha, Donat P Häder
Sep 8, 2004·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Cai-Hong ZhangYun-Bao Jiang
Apr 2, 2005·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Hirofumi ShimadaSeiji Tobita
Aug 28, 2007·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·W M KwokM Towrie
Mar 14, 2008·Journal of the American Chemical Society·Wai-Ming KwokDavid Lee Phillips
Dec 17, 2008·Journal of the American Chemical Society·Maxim ZakharovAndreas Dreuw
Oct 5, 2010·International Journal of Dermatology·Deevya L NarayananJoshua L Fox
Nov 11, 2011·Accounts of Chemical Research·Guang-Jiu Zhao, Ke-Li Han
Jan 24, 2012·Mutation Research. Reviews in Mutation Research·Lucymara F Agnez-LimaCarlos F M Menck
Jul 12, 2012·Photochemistry and Photobiology·Jean CadetThierry Douki
Aug 16, 2012·The Journal of Physical Chemistry. B·Fabrizio MessinaMajed Chergui
Mar 30, 2013·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Chopen Chan-Wut ChengWai-Ming Kwok
Jun 10, 2014·Journal of Cosmetic Dermatology·Charlene DeHavenJonathan Oldach
Oct 21, 2014·Photochemistry and Photobiology·Jean CadetJean-Luc Ravanat
Jan 13, 2015·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Marta T IgnasiakTomasz Pedzinski
Feb 11, 2015·Annual Review of Physical Chemistry·Wolfgang J SchreierWolfgang Zinth
Aug 19, 2015·The Journal of Physical Chemistry Letters·Eric M M TanWybren J Buma
Aug 22, 2015·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Lewis A BakerVasilios G Stavros
Oct 30, 2015·The Journal of Physical Chemistry. a·Xue-Ping ChangGanglong Cui
Dec 4, 2015·Journal of Molecular Modeling·Gustavo H G TrossiniAndré R Baby
Dec 15, 2015·The Journal of Physical Chemistry Letters·Lewis A BakerVasilios G Stavros
Jul 23, 2016·Physical Chemistry Chemical Physics : PCCP·Marko KojićMihajlo Etinski
Sep 23, 2016·The Journal of Physical Chemistry Letters·Kaoru YamazakiTakayuki Ebata
Oct 7, 2016·Physical Chemistry Chemical Physics : PCCP·Yoann PeperstraeteVasilios G Stavros
Oct 30, 2016·The Journal of Physical Chemistry Letters·Lewis A BakerVasilios G Stavros
Jan 1, 2017·Journal of the American Academy of Dermatology·Antony R YoungAna Beatris Rossi
Feb 7, 2017·Photodermatology, Photoimmunology & Photomedicine·Catherine M OlsenDavid C Whiteman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.