Photoprotective effect of coumarin and 3-hydroxycoumarin in sea urchin gametes and embryonic cells

Journal of Photochemistry and Photobiology. B, Biology
Jocelmo Cássio de Araujo LeiteLuis Fernando Marques-Santos

Abstract

Ultraviolet radiation B (UVB) represents 5% of all solar UV radiation and chronic exposure can induce harmful biological responses, including skin cancer. Prospection of new drugs with photoprotective properties and less toxic effects is constant and natural products have been the main options in this field. Coumarins are a group of natural phenolic compounds that shows several pharmacological activities. The aim of present work was to investigate the effect of coumarin and six derivatives in sea urchin gametes and zygotes exposed to UVB. Embryonic development assay was used to monitor UVB embryotoxicity. Firstly, we demonstrated that coumarin inhibited first embryonic cell division from 5 μM (EC50 = 52.9 μM) and its derivatives showed an embryotoxic effect ten times higher. Then, gametes or zygotes were treated with coumarin compounds before or after UVB exposure (UVB doses ranged from 0.056 to 0.9 kJm(-2)). Pretreatment of gametes or zygotes with coumarin or 3-hydroxycoumarin (1 μM, both) decreased UVB embryotoxic effect. Protective effect of the compounds was observed only when cells were treated previous to UVB exposure. Coumarin derivatives 4-hydroxycoumarin, 6-hydroxycoumarin, 7-hydroxycoumarin, 6,7-dihydroxycoumarin and ...Continue Reading

References

May 1, 1981·Archives of Dermatology·K H Kaidbey, A M Kligman
Aug 20, 2002·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·L V Costa-LotufoG M A Cunha
Nov 28, 2002·Chemico-biological Interactions·Takao KanekoMitsuyoshi Matsuo
Jun 5, 2003·Toxicon : Official Journal of the International Society on Toxinology·Espen HansenAnne-Marie Genevière
Mar 1, 1954·Archives of Biochemistry and Biophysics·R H GOODWIN, B M POLLOCK
Mar 24, 2004·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Alena SvobodováDaniela Walterová
Oct 7, 2004·Bioorganic & Medicinal Chemistry·Fabrice BaillyPhilippe Cotelle
Dec 8, 2004·Current Pharmaceutical Design·Konstantina C FylaktakidouDemetrios N Nicolaides
Jun 9, 2005·International Journal of Biological Macromolecules·Nívea M R MacedoMárcio V Ramos
Oct 6, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S P FelterG P Daston
Feb 9, 2006·Life Sciences·B Ramesh, K V Pugalendi
Nov 11, 2006·Science·Erica SodergrenRita Wright
Nov 11, 2006·Science·Manoj P SamantaViktor Stolc
May 5, 2007·European Journal of Pharmacology·Balakrishnan RameshKodukkur Viswanathan Pugalendi
Jan 1, 2008·Bioorganic & Medicinal Chemistry Letters·Adeline BeillerotDenyse Bagrel
Apr 18, 2008·Environmental and Molecular Mutagenesis·Sarah NahonAudrey M Pruski
Jun 17, 2008·Chemical Biology & Drug Design·Terence BeghynBenoit Deprez
Aug 30, 2008·European Journal of Medicinal Chemistry·S StanchevI Manolov
Sep 2, 2009·Biological & Pharmaceutical Bulletin·Phuong Thien ThuongKeon Wook Kang
Nov 10, 2009·Archives of Dermatological Research·Joi A Nichols, Santosh K Katiyar
Jan 6, 2010·Aquatic Toxicology·Hans-U Dahms, Jae-Seong Lee
Feb 23, 2010·European Journal of Medicinal Chemistry·Davide AudisioMouâd Alami
Jul 12, 2011·European Journal of Pharmacology·Fausto Alejandro Jiménez-OrozcoJuan José Mandoki
Mar 16, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jana DonovalováPavol Hrdlovič
Jun 12, 2013·International Journal of Molecular Sciences·John D'OrazioTimothy Scott
Nov 21, 2013·Molecular Reproduction and Development·Jocelmo Cássio de Araujo LeiteLuis Fernando Marques-Santos
Feb 27, 2014·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Yihui BaiXuexiang Weng
May 13, 2014·Journal of Photochemistry and Photobiology. B, Biology·A Pérez-SánchezV Micol

❮ Previous
Next ❯

Citations

Aug 12, 2015·Journal of Agricultural and Food Chemistry·Shailendra AsthanaAntonio Rescigno

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.