PMID: 9176679May 1, 1997Paper

Photoreceptor decay over time and apoptosis in experimental retinal detachment

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
L BerglinS Seregard

Abstract

Data are scarce on the actual rate and mode of outer nuclear layer decay in retinal detachment (RD). We used an experimental rabbit model to assess the presence of apoptosis and rate of photoreceptor death following RD. This model included the creation of localized and stable retinal blebs, while controlling for any decline of retinal elevation over time. RD was produced in New Zealand white rabbits by injecting 0.05 ml of 15% sodium hyaluronate (Healon GV) under the neural retina using a microsurgical technique. Animals were killed at 1, 2, 4, 7, 14 and 29 days. Retinal tissue was processed for light and electron microscopy and for in situ end labeling of fragmented DNA using a modification of the TUNEL technique. Photoreceptor cell nuclei were counted in the RD areas of maximum retinal elevation of 28 eyes, and an additional 4 eyes were used for nick end labeling. Positive DNA nick end labeling, ultrastructural features and absence of necrotic cells indicated apoptotic photoreceptor cell death. Also, there was a rapid, almost linear elimination of photoreceptor nuclei over time. At 14 days only half of the number of nuclei were discernible, while approximately one tenth remained after 29 days. There was a statistically signif...Continue Reading

References

Jul 14, 1975·Biochimica Et Biophysica Acta·M McCabe, T C Laurent
Apr 1, 1992·International Journal of Radiation Biology·R J CollinsJ F Kerr
Nov 1, 1992·The Journal of Cell Biology·Y GavrieliS A Ben-Sasson
Feb 1, 1992·The Journal of General Physiology·R A Linsenmeier, R D Braun
Jun 28, 1991·Cell·G T Williams
Jan 1, 1991·Current Eye Research·S ShahinfarM O Tso
Dec 1, 1968·American Journal of Ophthalmology·R Machemer
Jan 1, 1969·American Journal of Ophthalmology·A J Kroll, R Machemer
Jan 1, 1980·International Review of Cytology·A H WyllieA R Currie
Jul 1, 1995·Archives of Ophthalmology·C J ChangM O Tso
Jan 1, 1993·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J H WijsmanJ H van Dierendonck
Jun 1, 1994·Australian and New Zealand Journal of Medicine·J A SavigeJ C Duggan
Feb 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·C Portera-CailliauR Adler
Feb 1, 1993·British Journal of Cancer·A H Wyllie
Oct 1, 1995·Pathology International·Q LiuM Kikuchi

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Citations

Oct 30, 2008·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Marie-Laure RantyJean-Claude Quintyn
Oct 20, 1998·Progress in Retinal and Eye Research·C E ReméA Wenzel
Oct 26, 1999·Progress in Retinal and Eye Research·J StoneJ Peér
May 4, 2011·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Fang WuJ Vernon Odom
May 24, 2008·The Journal of Clinical Investigation·Toshio HisatomiJoan W Miller
Aug 15, 2014·Indian Journal of Ophthalmology·Vivek ChaturvediKourous A Rezaei
Jun 2, 2009·Japanese Journal of Ophthalmology·Atsushi HayashiEugene de Juan
Sep 26, 2008·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Olga KlebanovArieh S Solomon
Nov 27, 2009·American Journal of Ophthalmology·Yukitoshi ShimodaShoji Kishi
Oct 1, 2009·Clinical & Experimental Ophthalmology·Syed K Gibran, Kapil G Kapoor
Sep 13, 2006·Acta Ophthalmologica Scandinavica·Hana Abouzeid, Thomas J Wolfensberger
Feb 15, 2005·Progress in Retinal and Eye Research·Steven K FisherMark R Verardo
Nov 30, 2013·Mediators of Inflammation·Vito RomanoMario R Romano
Aug 17, 2014·American Journal of Ophthalmology·Shideh SchönfeldAntonia M Joussen
Dec 2, 2011·Korean Journal of Ophthalmology : KJO·Se Joon WooKyu Hyung Park
Jul 9, 2002·Eye·N G Ghazi, W R Green
Sep 11, 2002·Current Eye Research·Toshio HisatomiGuido Kroemer
May 17, 2003·European Journal of Ophthalmology·G Carella
Apr 14, 2020·Retina·Vilde M ThomsethVegard A Forsaa
Jan 13, 2021·Brain Research Bulletin·Zi-Yuan ZhangGuang-Yu Li
Oct 24, 2020·International Ophthalmology Clinics·Basil K Williams, Maura Di Nicola
May 13, 2021·Current Eye Research·Matthew R StarrUNKNOWN Primary Retinal Detachment Outcomes (PRO) Study Group

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