PMID: 9419388Jan 7, 1998Paper

Photoreceptor guanylate cyclases: a review

Bioscience Reports
E N PughR K Sharma

Abstract

Almost three decades of research in the field of photoreceptor guanylate cyclases are discussed in this review. Primarily, it focuses on the members of membrane-bound guanylate cyclases found in the outer segments of vertebrate rods. These cyclases represent a new guanylate cyclase subfamily, termed ROS-GC, which distinguishes itself from the peptide receptor guanylate cyclase family that it is not extracellularly regulated. It is regulated, instead, by the intracellularly-generated Ca2+ signals. A remarkable feature of this regulation is that ROS-GC is a transduction switch for both the low and high Ca2+ signals. The low Ca2+ signal transduction pathway is linked to phototransduction, but the physiological relevance of the high Ca2+ signal transduction pathway is not yet clear; it may be linked to neuronal synaptic activity. The review is divided into eight sections. In Section I, the field of guanylate cyclase is introduced and the scope of the review is briefly explained; Section II covers a brief history of the investigations and ideas surrounding the discovery of rod guanylate cyclase. The first five subsections of Section III review the experimental efforts to quantify the guanylate cyclase activity of rods, including in ...Continue Reading

Citations

Aug 25, 2001·Annual Review of Neuroscience·M E Burns, D A Baylor
Mar 20, 2003·Microscopy Research and Technique·Rosario Donato
Mar 19, 2008·The Journal of General Physiology·Wenkuan XinThomas C Rich
Nov 28, 2009·Molecular and Cellular Biochemistry·Karl-W KochRameshwar K Sharma
Nov 27, 2009·Molecular and Cellular Biochemistry·David M HuntMichel Michaelides
Feb 26, 2014·The Journal of Biological Chemistry·Igor V PeshenkoAlexander M Dizhoor
Apr 12, 2014·Frontiers in Molecular Neuroscience·Rameshwar K SharmaTeresa Duda
Jul 30, 2014·Frontiers in Molecular Neuroscience·Rameshwar K Sharma, Teresa Duda
Dec 20, 2013·Documenta Ophthalmologica. Advances in Ophthalmology·Eva NongStephen H Tsang
Feb 10, 2016·Frontiers in Molecular Neuroscience·Teresa DudaRameshwar K Sharma
Oct 4, 2016·Frontiers in Molecular Neuroscience·Rameshwar K SharmaClint L Makino
Aug 28, 1999·The Journal of Biological Chemistry·E V OlshevskayaA M Dizhoor
Jan 12, 2001·Physiological Reviews·G L FainY Koutalos
Oct 6, 2007·Molecular Neurobiology·Martin Biel, Stylianos Michalakis
Dec 17, 2009·Molecular and Cellular Biochemistry·Sukanya KaranWolfgang Baehr
Mar 29, 2014·Frontiers in Molecular Neuroscience·Teresa DudaRameshwar K Sharma
May 27, 2014·Frontiers in Molecular Neuroscience·Shannon E Boye
Apr 10, 1999·The Journal of Biological Chemistry·E V OlshevskayaA M Dizhoor
Dec 4, 2009·Molecular and Cellular Biochemistry·Rameshwar K Sharma
May 9, 2014·Frontiers in Molecular Neuroscience·Anna JankowskaTeresa Duda
Mar 10, 2018·International Journal of Molecular Sciences·Stylianos MichalakisMartin Biel
Aug 22, 2020·Translational Vision Science & Technology·Xiao LiuUNKNOWN Japan Eye Genetics Consortium
Feb 11, 2018·Molecular and Cellular Biochemistry·Teresa DudaRameshwar K Sharma
Jun 18, 2002·Journal of Cellular and Molecular Medicine·E KovácsK O Greulich
Feb 14, 1998·The Journal of General Physiology·S NikonovE N Pugh
Feb 5, 2021·Pflügers Archiv : European journal of physiology·Alexander M Dizhoor, Igor V Peshenko
Oct 9, 2002·Neuron·Marie E BurnsDenis A Baylor
May 8, 1998·Biochemical and Biophysical Research Communications·R M GoraczniakR K Sharma
Dec 3, 1999·Methods : a Companion to Methods in Enzymology·A M Dizhoor, J B Hurley
Nov 5, 1999·Experimental Eye Research·S L Semple-Rowland, K M Cheng

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.