Photoreceptor integrity and visual acuity in cystoid macular oedema associated with retinitis pigmentosa

Eye
A OishiNagahisa Yoshimura

Abstract

To assess the correlation between macular morphology and visual acuity in retinitis pigmentosa (RP) patients with cystoid macular oedema (CME). Retrospective cross-sectional study. Forty-one eyes of 25 RP patients with CME. Patients underwent cross-sectional scans with optical coherence tomography (Stratus OCT). Age, total retinal thickness, photoreceptor thickness, and the transverse and vertical lengths of the cystoid space were measured. Correlation between visual acuity and each of the measurements were examined. Additionally, the status of the inner segment/outer segment junction (IS/OS) was classified as being absent, discontinuous, or distinct. Measurements were then compared among the three groups. Total retinal thickness or photoreceptor thickness was not correlated with visual acuity. There was a correlation between the transverse length of the cystoid space and visual acuity, although the correlation coefficient was weak (r=0.30). The logMAR visual acuity in the IS/OS absent group (0.67+/-0.43) was worse than that seen in the IS/OS discontinuous (0.22+/-0.19) or IS/OS distinct groups (0.07+/-0.16) (P<0.001). When monitoring CME associated with RP, the status of IS/OS is the essential parameter that needs to be examined.

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Citations

Apr 24, 2012·Journal of Ophthalmology·Maria-Andreea GamulescuHorst Helbig
Dec 4, 2012·Indian Journal of Ophthalmology·Maho OishiNagahisa Yoshimura
Jan 21, 2014·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Emiko InuiNagahisa Yoshimura
Feb 16, 2013·Survey of Ophthalmology·Benjamin NicholsonCatherine Meyerle
Jul 9, 2010·American Journal of Ophthalmology·Akio OishiYasuo Kurimoto
Jul 20, 2014·Progress in Retinal and Eye Research·Nicolás CuencaIsabel Pinilla
Oct 18, 2016·Seminars in Ophthalmology·Rachel M Huckfeldt, Jason Comander
Dec 4, 2016·The British Journal of Ophthalmology·S StrongM Michaelides
Nov 16, 2017·Ophthalmic Epidemiology·Gerald LiewMichel Michaelides
Jun 20, 2020·Ophthalmic Genetics·Jin Kyun OhStephen H Tsang
May 12, 2011·Biomedical Optics Express·Donald C HoodVivienne C Greenstein
Feb 20, 2021·International Ophthalmology·Zübeyir YozgatSerpil Yazgan Akpolat
Apr 15, 2021·Klinische Monatsblätter für Augenheilkunde·Anna FriesacherMargarita G Todorova
Jul 30, 2021·Translational Vision Science & Technology·Tomoko HasegawaAkitaka Tsujikawa
Apr 16, 2010·Current Opinion in Ophthalmology

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